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Ablation of immunity to Amblyomma americanum by anti-basophil serum: cooperation between basophils and eosinophils in expression of immunity to ectoparasites (ticks) in guinea pigs.
Abstract
Basophils infiltrate the skin and other tissues as part of T lymphocyte and/or antibody-mediated immune responses to certain protein antigens, viruses, tumors, and parasites. Although basophils may comprise a significant fraction of leukocytes in these reactions, their precise role has been poorly understood. Guinea pigs expressing acquired immunity to the tick Amblyomma americanum develop basophil- and eosinophil-rich cutaneous inflammatory responses at tick feeding sites, and tick rejection is associated with extensive local basophil degranulation. We report that a specific anti-basophil serum (ABS) eliminate basophils at tick feeding sites and abolished immunity to A. americanum. ABS does not react with eosinophils and did not reduce blood or bone marrow eosinophils; however, ABS-treated animals had diminished eosinophils at tick feeding sites, perhaps because these sites were deficient in basophil-derived eosinophil-chemotactic factors. AES treatment markedly reduced feeding site eosinophils, did not affect basophil levels, and partially impaired tick resistance. Taken together, our experiments suggest cooperation between basophils and eosinophils in the expression of immunity to ticks in guinea pigs.
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In the citing paper
“Brown et al. found that treatment of tick-sensitized guinea pigs with rabbit ABS markedly diminished basophils in the bone marrow, blood, and skin at sites of tick feeding of the sensitized guinea pigs, and also resulted in diminished numbers of eosinophils at such feeding sites [45].”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [45]
In the citing paper
“To our knowledge, this was the first in vivo experimental evidence that went beyond correlative and observational studies (i.e., demonstrating the presence of basophils at tick feeding sites) indicating that basophils might represent one important component of acquired, antibody-dependent resistance to the feeding of an arthropod.”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [45]
In the citing paper
“Treatment with rabbit AES had a lesser, but still statistically significant, effect on tick feeding success, whereas normal rabbit serum was without effect (Fig. 1) [45].”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [45]
In the citing paper
“Notably, ABS treatment also essentially ablated the acquired resistance to tick feeding conferred by sensitization (Fig. 1) [45].”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [45]
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Galli, S. J., & Tsai, M. (2010) · European Journal of Immunology · doi:10.1002/eji.201040559 · Cited by 403
Self-citationMast cells and IgE in defense against venoms: Possible “good side” of allergy?
Galli, S. J., Starkl, P., Marichal, T., & Tsai, M. (2016) · Allergology International · doi:10.1016/j.alit.2015.09.002 · Cited by 73
Self-citationMast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy
Galli, S. J., Metz, M., Starkl, P., Marichal, T., & Tsai, M. (2020) · Allergo Journal International · doi:10.1007/s40629-020-00118-6 · Cited by 57
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Metadata
- Authors
- Brown, S. J., Galli, S. J., Gleich, G. J., & Askenase, P. W.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1982-08-01
- Volume
- 129
- Issue
- 2
- Pages
- 790-796
- ISSN
- 0022-1767
- 1550-6606
- Cited by
- 136
- References
- 0
- Language
- en
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- CoChat. (2026). Citation check: Ablation of immunity to Amblyomma americanum by anti-basophil serum: cooperation between basophils and eosinophils in expression of immunity to ectoparasites (ticks) in guinea pigs. https://app.cochat.ai/papers/10.4049/jimmunol.129.2.790
- The paper
- Brown, S. J., Galli, S. J., Gleich, G. J., & Askenase, P. W. (1982). Ablation of immunity to Amblyomma americanum by anti-basophil serum: cooperation between basophils and eosinophils in expression of immunity to ectoparasites (ticks) in guinea pigs. The Journal of Immunology. https://doi.org/10.4049/jimmunol.129.2.790
