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Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production.
Abstract
Corticosteroids have profound effects on functions of the macrophage associated with antigen presentation to T cells. The drugs inhibited the expression of surface I-region-associated (Ia) antigens by peritoneal macrophages both in vitro and in vivo, reduced the production of IL 1, and inhibited antigen presentation for T cell proliferation by macrophages. The doses of hydrocortisone and prednisolone that inhibited by 50% Ia expression in cultured macrophages ranged around 2 to 5 x 10(-8) M. These results could explain one mechanism by which corticosteroids suppress the induction of immune responses.
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Citations
Cited by
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones
Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986) · Science · doi:10.1126/science.3014662 · Cited by 1,519
There is more than one interleukin 1
Oppenheim, J. J., Kovacs, E. J., Matsushima, K., & Durum, S. K. (1986) · Immunology Today · doi:10.1016/0167-5699(86)90124-6 · Cited by 1,203
Evidence for an immune response in major depression: A review and hypothesis
Maes, M. (1995) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(94)00101-m · Cited by 1,003
Sternberg, E. M., Hill, J. M., Chrousos, G. P., Kamilaris, T., Listwak, S. J., Gold, P. W., & Wilder, R. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2374 · Cited by 723
Metadata
- Authors
- Snyder, D. S., & Unanue, E. R.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1982-11-01
- Volume
- 129
- Issue
- 5
- Pages
- 1803-1805
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2104938127
- Cited by
- 649
- References
- 0
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Snyder, D. S., & Unanue, E. R. (1982). Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production. The Journal of Immunology. https://doi.org/10.4049/jimmunol.129.5.1803
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