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Abnormalities induced by the mutant gene Ipr: expansion of a unique lymphocyte subset.
Abstract
Mice carrying the Ipr mutation develop massive lymphoadenopathy and severe autoimmune disease. The characteristics of the cell population that proliferates in lymphoid tissues were evaluated by the use of a) monoclonal antibodies and FMF, and b) molecular genetic studies of Ig heavy chain genes. The lymph node cells of different strains of mice homozygous for the Ipr mutation were shown to be almost uniformly Thy-1+, Ly-1+, Ly-2-, H-11+, Ly-5+, sIg-, ThB-, 2C2+, I-A-, 6B2+, and therefore to have surface characteristics of both T and B cells. Molecular genetic studies of the arrangements of Ig heavy chain genes showed that they were not rearranged as in pre-B and B cells. These results suggest that an abnormal proliferating population of T cells in Ipr/Ipr mice aberrantly express B cell surface markers.
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Cited by
A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice.
Roths, J. B., Murphy, E. D., & Eicher, E. M. (1984) · The Journal of experimental medicine · doi:10.1084/jem.159.1.1 · Cited by 299
Self-citationT cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy
Yamamoto, T. N., Lee, P.-H., Vodnala, S. K., Gurusamy, D., Kishton, R. J., Yu, Z., Eidizadeh, A., Eil, R., Fioravanti, J., Gattinoni, L., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci121491 · Cited by 156
Metadata
- Authors
- Morse, H. C., Davidson, W. F., Yetter, R. A., Murphy, E. D., Roths, J. B., & Coffman, R. L.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1982-12-01
- Volume
- 129
- Issue
- 6
- Pages
- 2612-2615
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1569831030
- Cited by
- 291
- References
- 0
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Abnormalities induced by the mutant gene Ipr: expansion of a unique lymphocyte subset. https://app.cochat.ai/papers/10.4049/jimmunol.129.6.2612
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- Morse, H. C., Davidson, W. F., Yetter, R. A., Murphy, E. D., Roths, J. B., & Coffman, R. L. (1982). Abnormalities induced by the mutant gene Ipr: expansion of a unique lymphocyte subset. The Journal of Immunology. https://doi.org/10.4049/jimmunol.129.6.2612
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