STAT-3 activation by differential cytokines is critical for human in vivo-generated plasma cell survival and Ig secretion
Open accessAbstract
Maturation and survival of plasma cells (PCs) depends on extrinsic factors provided in specialized niches. In addition, B lymphocyte differentiation into PCs requires the activation of the JAK–STAT-3 pathway. However, whether STAT-3 is needed only during the transition of B lymphocytes to PC, or it is also involved in the survival and function of PCs at different stages of maturation, has not been unequivocally clarified. This study analyzes the effect of IL-10, IL-21, and IL-6 on human in vivo–generated PCs isolated from secondary lymphoid organs, blood (circulating, recently Ag-induced PCs), and bone marrow. PCs from these different organs show specific profiles of receptors for, and responsiveness to, these cytokines required for their survival and sustained Ab secretion. However, IL-10, IL-21, and IL-6 commonly induce STAT-3 phosphorylation in the three PC subsets, and all of their effects are exerted strictly through the STAT-3 activation. The inhibition or nonactivation of this pathway in the three PC populations impairs not only the effect of STAT-3–activating cytokines, but also the action of other cytokines important at the PC level, including a proliferation-induced ligand, BAFF, insulin-like growth factor 1, vascular endothelial growth factor, and stromal cell–derived factor-1α. These results indicate that STAT-3 activation is critical for human PCs throughout their maturation.
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IL-6-induced STAT3 activation is critical for in vivo plasma cell survival and immunoglobulin secretion in humans.
“IL-6-induced STAT3 activation is critical for in vivo plasma cell survival and immunoglobulin secretion in humans (154).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [154]
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- Authors
- Rodríguez-Bayona, B., Ramos-Amaya, A., López-Blanco, R., Campos-Caro, A., & Brieva, J. A.
- Affiliations
- Unidad de Investigación, Hospital Universitario Puerta del Mar , 11009 Cádiz,
- Hospital Universitario Puerta del Mar (ES)
- Corresponding author
- Brieva, José A
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-11
- Volume
- 191
- Issue
- 10
- Pages
- 4996-5004
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2148437680
- Cited by
- 53
- References
- 0
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 3 · 2015: 6 · 2014: 8
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- STAT3, plasma cell survival, immunoglobulin secretion, JAK/STAT signaling, IL-10, IL-21, interleukin-6, plasma cell maturation, B cell differentiation, BAFF, stromal cell-derived factor-1α, vascular endothelial growth factor, insulin-like growth factor I, secondary lymphoid organs, bone marrow plasma cells, circulating plasma cells
- MeSH terms
- Interleukin-21, B-Lymphocytes, Bone Marrow Cells, Cell Differentiation, Cell Survival, Cells, Cultured, Enzyme Activation, Humans, Immunoglobulins, Insulin-Like Growth Factor I, Interleukins, Lymphocyte Activation, Phosphorylation, Plasma Cells, RNA, Messenger, Interleukin-6, Interleukin-10, Vascular Endothelial Growth Factor A, STAT3 Transcription Factor, B-Cell Activating Factor, Chemokine CXCL12
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