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Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody.
Abstract
By using a murine monoclonal antibody produced against an IL 2-dependent human T cell line, we defined a T lineage-specific molecule, termed Ta1, that is expressed strongly on activated T lymphocytes of both the T4 and T8 subsets, as well as on T cell lines and clones, but only weakly on a fraction of resting T cells. SDS-PAGE analysis of immunoprecipitates from 125I-labeled, activated T cells demonstrates a single major band of apparent m.w. 105 KD under both reducing and nonreducing conditions. Unlike anti-IL 2 receptor antibodies, anti-Ta1 does not inhibit T cell proliferative responses to mitogen, antigen, or IL 2-containing medium. Moreover, anti-Ta1 has no effect on T cell-mediated cytotoxicity. Ta1 appears to be a novel human T cell-specific activation antigen that may serve as a useful marker of T cell activation in human disease.
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Citations
Cited by
Contingent Genetic Regulatory Events in T Lymphocyte Activation
Crabtree, G. R. (1989) · Science · doi:10.1126/science.2783497 · Cited by 1,072
Efficacy of Low-Dose Methotrexate in Rheumatoid Arthritis
Weinblatt, M. E., Coblyn, J. S., Fox, D. A., Fraser, P. A., Holdsworth, D. E., Glass, D. N., & Trentham, D. E. (1985) · New England Journal of Medicine · doi:10.1056/nejm198503283121303 · Cited by 872
Self-citationDirect Association of Adenosine Deaminase with a T Cell Activation Antigen, CD26
Kameoka, J., Tanaka, T., Nojima, Y., Schlossman, S. F., & Morimoto, C. (1993) · Science · doi:10.1126/science.8101391 · Cited by 507
Ullman, K. S., Northrop, J. P., Verweij, C. L., & Crabtree, G. R. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.002225 · Cited by 503
The multifunctional or moonlighting protein CD26/DPPIV
Boonacker, E., & Van Noorden, C. J. F. (2003) · European Journal of Cell Biology · doi:10.1078/0171-9335-00302 · Cited by 337
Metadata
- Authors
- Fox, D. A., Hussey, R. E., Fitzgerald, K. A., Acuto, O., Poole, C., Palley, L., Daley, J. F., Schlossmann, S. F., & Reinherz, E. L.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1984-09-01
- Volume
- 133
- Issue
- 3
- Pages
- 1250-1256
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1909461041
- Cited by
- 235
- References
- 0
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody. https://app.cochat.ai/papers/10.4049/jimmunol.133.3.1250
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- Fox, D. A., Hussey, R. E., Fitzgerald, K. A., Acuto, O., Poole, C., Palley, L., Daley, J. F., Schlossmann, S. F., & Reinherz, E. L. (1984). Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody. The Journal of Immunology. https://doi.org/10.4049/jimmunol.133.3.1250
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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