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Inhibition of human cytotoxic T lymphocyte activity in vitro by autologous peripheral blood granulocytes.
Abstract
Peripheral blood granulocytes from normal healthy donors were found to reproducibly inhibit the cytolytic effector function of specifically sensitized cytotoxic T lymphocytes in vitro when co-incubated with these effector cells and target cells in 8 hr 51Cr release assays. Inhibition required intact granulocytes, was proportional to the number of granulocytes present, and was independent of granulocyte adherence, phagocytic function, and viability. Equivalent numbers of enriched normal or leukemic peripheral T lymphocytes did not cause inhibition of 51Cr release, and preincubation of granulocytes with effectors did not significantly alter viability or cytotoxic function. Because granulocytes can inhibit natural killer cell function in vitro, these data indicate that granulocytes can regulate diverse antigen-specific and spontaneous cytotoxic functions in vitro, suggesting that circulating granulocytes may have the potential for in vivo regulation of these cytotoxic effectors.
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Cited by
Templeton, A. J., McNamara, M. G., Šeruga, B., Vera-Badillo, F. E., Aneja, P., Ocaña, A., Leibowitz-Amit, R., Sonpavde, G., Knox, J. J., Tran, B., et al. (2014) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/dju124 · Cited by 2,829
Templeton, A. J., Ace, O., McNamara, M. G., Al-Mubarak, M., Vera-Badillo, F. E., Hermanns, T., Šeruga, B., Ocaña, A., Tannock, I. F., & Amir, E. (2014) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-14-0146 · Cited by 719
Li, M.-X., Liu, X.-M., Zhang, X.-F., Zhang, J.-F., Wang, W.-L., Zhu, Y., Dong, J., Cheng, J.-W., Liu, Z.-W., Ma, L., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.28536 · Cited by 459
Yamanaka, T., Matsumoto, S., Teramukai, S., Ishiwata, R., Nagai, Y., & Fukushima, M. (2007) · Oncology · doi:10.1159/000127412 · Cited by 454
Neutrophil-to-lymphocyte ratio and mortality in the United States general population
Song, M., Graubard, B. I., Rabkin, C. S., & Engels, E. A. (2021) · Scientific Reports · doi:10.1038/s41598-020-79431-7 · Cited by 434
Metadata
- Authors
- Petrie, H. T., Klassen, L. W., & Kay, H. D.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1985-01-01
- Volume
- 134
- Issue
- 1
- Pages
- 230-234
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1658971720
- Cited by
- 253
- References
- 0
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Inhibition of human cytotoxic T lymphocyte activity in vitro by autologous peripheral blood granulocytes. https://app.cochat.ai/papers/10.4049/jimmunol.134.1.230
- The paper
- Petrie, H. T., Klassen, L. W., & Kay, H. D. (1985). Inhibition of human cytotoxic T lymphocyte activity in vitro by autologous peripheral blood granulocytes. The Journal of Immunology. https://doi.org/10.4049/jimmunol.134.1.230
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
