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Modulation of lymphocyte function by sensory neuropeptides
Abstract
Neuropeptides present in the peripheral nervous system (PNS) and central nervous system (CNS) modify diverse functions of human, murine and guinea pig mononuclear leukocytes in vitro and in vivo by receptor-mediated mechanisms. Both stimulatory and inhibitory effects on lymphocytes and macrophages have been demonstrated for different neuropeptides in vitro at concentrations which are similar to those in the circulation and in tissues. The dissociation constant (KD) for the binding of a neuropeptide to its lymphocyte receptor is within the range of concentrations that evoke lymphocyte responses critical to immunity and hypersensitivity. The receptor-mediated interactions of diverse neuropeptides with immunocompetent cells provide one mechanism through which the PNS may influence localized immune responses and the CNS may alter systemic immunity.
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Cited by
The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation
Chrousos, G. P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322008 · Cited by 2,579
Noradrenergic Sympathetic Neural Interactions with the Immune System: Structure and Function
Felten, D. L., Felten, S. Y., Bellinger, D. L., Carlson, S. L., Ackerman, K. D., Madden, K. S., Olschowki, J. A., & Livnat, S. (1987) · Immunological Reviews · doi:10.1111/j.1600-065x.1987.tb00534.x · Cited by 746
Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ
Roosterman, D., Goerge, T., Schneider, S. W., Bunnett, N. W., & Steinhoff, M. (2006) · Physiological Reviews · doi:10.1152/physrev.00026.2005 · Cited by 665
Karalis, K., Muglia, L. J., Bae, D., Hilderbrand, H., & Majzoub, J. A. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(96)00178-6 · Cited by 203
Metadata
- Authors
- Payan, D. G., & Goetzl, E. J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1985-08-01
- Volume
- 135
- Issue
- 2
- Pages
- 783-786
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2425396734
- Cited by
- 161
- References
- 0
- FWCI
- 5.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Payan, D. G., & Goetzl, E. J. (1985). Modulation of lymphocyte function by sensory neuropeptides. The Journal of Immunology. https://doi.org/10.4049/jimmunol.135.2.783
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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