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Different subclass distribution of IgA-producing cells in human lymphoid organs and various secretory tissues.
Abstract
A highly reproducible paired immunofluorescence staining method was used to map the relative distribution of IgA1- and IgA2-producing cells in peripheral lymphoid organs and various secretory tissues. Spleen, peripheral lymph nodes, and tonsils all contained a marked predominance (91 to 95%) of IgA1 immunocytes. However, striking variations were demonstrated among the secretory tissues with regard to the median proportion of IgA1-producing cells: nasal mucosa, 96%; lacrimal glands, 81%; major salivary glands, 66%; mammary glands, 63%; gastric and proximal small intestinal mucosa, 84 to 77%; ileum, 55%; and large bowel, 41%. Thus, IgA2 production is relatively enhanced mainly in the distal gut and in mammary and salivary glands, in that order.
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Citations
Cited by
Regional specialization within the intestinal immune system
Mowat, A. M., & Agace, W. W. (2014) · Nature Reviews Immunology · doi:10.1038/nri3738 · Cited by 1,756
He, B., Xu, W., Santini, P. A., Polydorides, A. D., Chiu, A., Estrella, J., Shan, M., Chadburn, A., Villanacci, V., Plebani, A., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.014 · Cited by 745
Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties
Brandtzaeg, P., & Johansen, F. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00283.x · Cited by 447
Self-citationBerkowska, M. A., Driessen, G. J. A., Bikos, V., Grosserichter-Wagener, C., Stamatopoulos, K., Cerutti, A., He, B., Biermann, K., Lange, J. F., van der Burg, M., et al. (2011) · Blood · doi:10.1182/blood-2011-04-345579 · Cited by 360
Kilian, M., Mestecky, J. F., & Russell, M. W. (1988) · Microbiological Reviews · doi:10.1128/mmbr.52.2.296-303.1988 · Cited by 316
Metadata
- Authors
- Kett, K., Brandtzaeg, P., Radl, J., & Haaijman, J. J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1986-05
- Volume
- 136
- Issue
- 10
- Pages
- 3631-3635
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1487246808
- Cited by
- 255
- References
- 0
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kett, K., Brandtzaeg, P., Radl, J., & Haaijman, J. J. (1986). Different subclass distribution of IgA-producing cells in human lymphoid organs and various secretory tissues. The Journal of Immunology. https://doi.org/10.4049/jimmunol.136.10.3631
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
