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A mouse T cell product that preferentially enhances IgA production. I. Biologic characterization.
Abstract
Supernatants from a subset of helper T cell clones can enhance IgA, IgE, and IgG1 production in cultures of lipopolysaccharide-stimulated, T cell-depleted spleen cells. The lymphokine interleukin (IL)-4 has been shown to cause the IgE and IgG1 enhancement produced by these supernatants. IgA enhancement, however, is mediated by a factor distinct from IL-4, although IL-4 can potentiate the effect of the IgA-enhancing factor. IgA-enhancing factor is also distinct from IL-1, IL-2, IL-3, granulocyte-macrophage colony-stimulating factor, and interferon-gamma and acts directly on B cells. Purified IgA-enhancing factor enhances IgA production three- to sixfold yet causes less than a twofold increase in other isotypes. The IgA enhancing activity is not inhibited by concentrations of interferon-gamma that inhibit IL-4 activities. In the accompanying article, we show that this IgA enhancing activity is a novel property of the lymphokine IL-5.
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Cited by
Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells
Stevens, T. L., Bossie, A., Sanders, V. M., Fernandez-Botran, R., Coffman, R. L., Mosmann, T. R., & Vitetta, E. S. (1988) · Nature · doi:10.1038/334255a0 · Cited by 933
Self-citationNALT- versus PEYER'S-patch-mediated mucosal immunity
Kiyono, H., & Fukuyama, S. (2004) · Nature Reviews Immunology · doi:10.1038/nri1439 · Cited by 745
Regulation of IgA synthesis and immune response by T cells and interleukins
McGhee, J. R., Mestecky, J., Elson, C. O., & Kiyono, H. (1989) · Journal of Clinical Immunology · doi:10.1007/bf00916814 · Cited by 276
Powe, D. G., Groot Kormelink, T., Sisson, M., Blokhuis, B. J., Kramer, M. F., Jones, N. S., & Redegeld, F. A. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.07.025 · Cited by 87
Metadata
- Authors
- Coffman, R. L., Shrader, B., Carty, J., Mosmann, T. R., & Bond, M. W.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1987-12-01
- Volume
- 139
- Issue
- 11
- Pages
- 3685-3690
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1542650808
- Cited by
- 195
- References
- 0
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Coffman, R. L., Shrader, B., Carty, J., Mosmann, T. R., & Bond, M. W. (1987). A mouse T cell product that preferentially enhances IgA production. I. Biologic characterization. The Journal of Immunology. https://doi.org/10.4049/jimmunol.139.11.3685
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