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Adherence induces selective mRNA expression of monocyte mediators and proto-oncogenes.
Abstract
Adherence is an important regulatory signal for several monokines and the proto-oncogenes c-fms and c-fos in human peripheral blood monocytes. Although there is little if any constitutive expression of the IL-1 beta, TNF-alpha and CSF-1 genes in freshly isolated monocytes, adherence is sufficient to induce high steady-state levels of mRNA for TNF and c-fos and more slowly that of CSF-1. Expression of mRNA for the CSF-1R gene, c-fms, was transiently down-regulated by 4 h. In contrast, the induction of high levels of IL-1 beta mRNA were achieved independent of culture conditions. Although all of these genes could be induced by adherence, actual secretion of the mediators required the exposure to a second signal derived from LPS. Thus adherence rapidly primes monocytes for a variety of inflammatory responses, the magnitude of which depends on the nature of a second "activating" signal. It is likely that some of these products act locally as paracrine or autocrine factors to further regulate the phenotype of the differentiating macrophage.
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Metadata
- Authors
- Haskill, S., Johnson, C., Eierman, D., Becker, S., & Warren, K.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1988-03-01
- Volume
- 140
- Issue
- 5
- Pages
- 1690-1694
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1527149701
- Cited by
- 393
- References
- 0
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- closed
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