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Cited by 40Phagocytosis and Immune RegulationMicroRNA in disease regulationCell death mechanisms and regulation

MicroRNA-34a Negatively Regulates Efferocytosis by Tissue Macrophages in Part via SIRT1

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McCubbrey, Alexandra L, Nelson, Joshua D, Stolberg, Valerie R, Blakely, Pennelope K, McCloskey, Lisa, Janssen, William J, Freeman, Christine M, Curtis, Jeffrey L·2016·The Journal of Immunology
DOI 10.4049/jimmunol.1401838PMC PMC4724467
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Abstract

Apoptotic cell (AC) clearance (efferocytosis) is an evolutionarily conserved process essential for immune health, particularly to maintain self-tolerance. Despite identification of many recognition receptors and intracellular signaling components of efferocytosis, its negative regulation remains incompletely understood and has not previously been known to involve microRNAs (miRs). In this article, we show that miR-34a (gene ID 407040), well recognized as a p53-dependent tumor suppressor, mediates coordinated negative regulation of efferocytosis by resident murine and human tissue macrophages (Mø). The miR-34a expression varied greatly between Mø from different tissues, correlating inversely with their capacity for AC uptake. Transient or genetic knockdown of miR-34a increased efferocytosis, whereas miR-34a overexpression decreased efferocytosis, without altering recognition of live, necrotic, or Ig-opsonized cells. The inhibitory effect of miR-34a was mediated both by reduced expression of Axl, a receptor tyrosine kinase known to recognize AC, and of the deacetylase silent information regulator T1, which had not previously been linked to efferocytosis by tissue Mø. Exposure to AC downregulated Mø miR-34a expression, resulting in a positive feedback loop that increased subsequent capacity to engulf AC. These findings demonstrate that miR-34a both specifically regulates and is regulated by efferocytosis. Given the ability of efferocytosis to polarize ingesting Mø uniquely and to reduce their host-defense functions, dynamic negative regulation by miR-34a provides one means of fine-tuning Mø behavior toward AC in specific tissue environments with differing potentials for microbial exposure.

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  • miR-34a negatively regulates efferocytosis via SIRT1.

    “MicroRNA-34a negatively regulates efferocytosis via SIRT1 [133].”

    From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [133]

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Cited by

Sorted by citations

Authors
McCubbrey, A. L., Nelson, J. D., Stolberg, V. R., Blakely, P. K., McCloskey, L., Janssen, W. J., Freeman, C. M., & Curtis, J. L.
Affiliations
  • Michigan Medicine (US)
  • VA Ann Arbor Healthcare System (US)
  • National Jewish Health (US)
Corresponding author
Curtis, Jeffrey L
ORCID
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2016-02-01
Volume
196
Issue
3
Pages
1366-1375
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.1401838
PMC
PMC4724467
OpenAlex
W2222799219
Cited by
40
References
5
Citations by year
2026: 2 · 2025: 5 · 2024: 1 · 2023: 6 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 2
FWCI
1.48
Type
journal article
Language
en
Open access
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Veterans Affairs (I01 CX000911, U01 HL098961, CX000911, BX001389, I01 BX001389)
  • National Institutes of Health (5t32ai007413-32, VA999999)
  • U.S. Public Health Service
  • National Heart, Lung, and Blood Institute (U01HL098961, R01HL109517)
  • National Institute of Allergy and Infectious Diseases (T32-AI-007413)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords
miR-34a, efferocytosis, tissue macrophages, SIRT1, AXL receptor, receptor tyrosine kinase, macrophage polarization, positive feedback loop, self-tolerance
MeSH terms
Animals, Flow Cytometry, Humans, Macrophages, Mice, Inbred C57BL, Phagocytosis, Transfection, Apoptosis, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Mice, Gene Knockdown Techniques, Sirtuin 1

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