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1F7, A novel cell surface molecule, involved in helper function of CD4 cells
Abstract
We have developed a monoclonal antibody, anti-1F7, that inhibits soluble Ag-driven T cell proliferation as well as PWM-driven IgG synthesis. Anti-1F7 antibody reacts with approximately 57% of unfractionated T cells, 62% of CD4+ cells, and 54% of CD8+ cells. Although the 1F7 Ag is widely distributed among lymphoid cells, this Ag on CD4+ cells is preferentially expressed on the CDw29(4B4+) helper population. Moreover, anti-1F7 antibody further subdivides the CD4+CDw29+ cell subset into CDw29+1F7+ and CDw29+1F7- populations. The CD4+CDw29+1F7+ population of cells maximally proliferates to recall Ag such as tetanus toxoid, whereas helper function for PWM-driven IgG synthesis by B cells belongs to both the CD4+CDw29+1F7+ and CD4+CDw29+1F7- population of cells. The most prominent structure defined by this antibody is a 110-kDa molecule that is different from the 135-kDa, 160-kDa, and 185-kDa glycoproteins identified by anti-CDw29 antibody and the 180-kDa glycoprotein identified by UCHL-1 antibody. It is, however, related to the molecule recognized by anti-Ta1, an activation Ag on T cells. Furthermore, although the Ta1 molecule is recognized by anti-1F7 mAb, the 1F7 family of structures also includes molecules distinct from Ta1.
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Cited by
The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes
Bleul, C. C., Wu, L., Hoxie, J. A., Springer, T. A., & Mackay, C. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.1925 · Cited by 1,134
Lambeir, A.-M., Durinx, C., Scharpé, S., & De Meester, I. (2003) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/713609354 · Cited by 955
Direct Association of Adenosine Deaminase with a T Cell Activation Antigen, CD26
Kameoka, J., Tanaka, T., Nojima, Y., Schlossman, S. F., & Morimoto, C. (1993) · Science · doi:10.1126/science.8101391 · Cited by 507
Self-citationThe multifunctional or moonlighting protein CD26/DPPIV
Boonacker, E., & Van Noorden, C. J. F. (2003) · European Journal of Cell Biology · doi:10.1078/0171-9335-00302 · Cited by 337
Metadata
- Authors
- Morimoto, C., Torimoto, Y., Levinson, G., Rudd, C. E., Schrieber, M., Dang, N. H., Letvin, N. L., & Schlossman, S. F.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-03-01
- Volume
- 144
- Issue
- 5
- Pages
- 2027-2027
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1521310551
- Cited by
- 175
- References
- 0
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: 1F7, A novel cell surface molecule, involved in helper function of CD4 cells. https://app.cochat.ai/papers/10.4049/jimmunol.144.5.2027
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- Morimoto, C., Torimoto, Y., Levinson, G., Rudd, C. E., Schrieber, M., Dang, N. H., Letvin, N. L., & Schlossman, S. F. (1990). 1F7, A novel cell surface molecule, involved in helper function of CD4 cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.144.5.2027
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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