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Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation.
Abstract
A cDNA clone encoding the human lymphocyte differentiation Ag CD38 was isolated from a mixture of four different lymphocyte CDNA libraries expressed transiently in COS cells and screened by panning with mAb. Transfected COS cells expressed a surface protein of Mr 46,000 that was similar to the native CD38 molecule expressed on the B cell line Daudi and the T cell leukemia HPB-ALL and which was recognized by each of the CD38 specific mAb HIT-2, T16, T168, HB7, 5D2, ICO-18, and ICO-20. The CD38 cDNA sequence predicts an unusual 30-kDa polypeptide with a short N-terminal cytoplasmic tail, and a carboxyl-terminal extracellular domain carrying the four potential N-linked glycosylation sites. The absence of significant homology with other known surface Ag including members of the Ig superfamily ruled out the possibility that CD38 was the human homologue of the murine Qa2 molecule as has been suggested previously. PvuII digests of human genomic DNA revealed a polymorphism linked to the CD38 gene.
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“CD38 is ubiquitously expressed by immune cells, and its expression increases during inflammatory conditions8-10.”
From Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages (2020) · cites this paper as [8]
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Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648
“In addition, recent topological studies have described the enzymatic activity of this transmembrane protein as both extra- and intra-cellular (Jackson and Bell, 1990; Lee, 2012; Zhao et al., 2012).”
BackgroundCallan, M. F. C., Tan, L., Annels, N., Ogg, G. S., Wilson, J. D. K., O'Callaghan, C. A., Steven, N., McMichael, A. J., & Rickinson, A. B. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.9.1395 · Cited by 892
Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology
Malavasi, F., Deaglio, S., Funaro, A., Ferrero, E., Horenstein, A. L., Ortolan, E., Vaisitti, T., & Aydin, S. (2008) · Physiological Reviews · doi:10.1152/physrev.00035.2007 · Cited by 862
“Direct cloning (169) ruled out the possibility of homology with murine Qa2.”
BackgroundFormation and Hydrolysis of Cyclic ADP-Ribose Catalyzed by Lymphocyte Antigen CD38
Howard, M., Grimaldi, J. C., Bazán, J. F., Lund, F. E., Santos‐Argumedo, L., Parkhouse, R. M. E., Walseth, T. F., & Lee, H. C. (1993) · Science · doi:10.1126/science.8235624 · Cited by 737
Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers
Lee, H. C. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.317 · Cited by 433
Metadata
- Authors
- Jackson, D. G., & Bell, J. I.
- Affiliations
- John Radcliffe Hospital (GB)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-04-01
- Volume
- 144
- Issue
- 7
- Pages
- 2811-2815
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1566643819
- Cited by
- 343
- References
- 0
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 10 · 2021: 3 · 2020: 13 · 2019: 9 · 2018: 8 · 2017: 6 · 2016: 6 · 2015: 5 · 2014: 6 · 2013: 5 · 2012: 10
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- CD38, lymphocyte differentiation antigens, cDNA cloning, cell surface glycoproteins, lymphocyte differentiation, B cells, T cells, monoclonal antibodies, N-glycosylation, cytoplasmic tail, genetic polymorphism, Daudi cells
- MeSH terms
- Amino Acid Sequence, Antigens, Differentiation, Base Sequence, Cloning, Molecular, DNA, Genes, Humans, Lymphocytes, Membrane Glycoproteins, Molecular Sequence Data, Molecular Weight, Solubility, Transfection, Blotting, Southern, Antigens, CD, Gene Expression, ADP-ribosyl Cyclase, ADP-ribosyl Cyclase 1
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