The DOI matches its Crossref record.
Tumor necrosis factor- alpha synergizes with IFN- gamma in mediating killing of Leishmania major through the induction of nitric oxide.
Abstract
CBA mice develop cutaneous lesions when infected with Leishmania major. The disease development was significantly reduced by injecting into the lesion a combination of rIFN-gamma and rTNF-alpha. The doses of IFN-gamma and TNF-alpha used were suboptimal in that either cytokine alone did not have any effect. The therapeutic effect of IFN-gamma and TNF-alpha in vivo is reflected in their ability to activate macrophages to kill the intracellular parasites in vitro. The macrophage leishmanicidal activity induced by TNF-alpha and IFN-gamma can be completely inhibited by a specific inhibitor (l-NG monomethyl arginine) of nitric oxide synthesis. There was a direct correlation between the intracellular killing of the parasites and the production of nitric oxide by the macrophages. In contrast, there was no correlation between leishmanicidal activity and superoxide production by macrophages.
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“It is worth noting that IFNγ co-operates with other TH1 cell cytokines and acts synergistically to enhance their ability to eliminate pathogens31,32.”
From An Omicron-specific, self-amplifying mRNA booster vaccine for COVID-19: a phase 2/3 randomized trial (2024) · cites this paper as [32]
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Louboutin, J., Rouger, K., Tinsley, J. M., Halldorson, J., & Wilson, J. M. (2000) · HAL
The Role of the Immune System in Resistance to Infection
Kedzierski, Ł., & Evans, K. J. (2012) · Springer eBooks · doi:10.1007/978-3-7091-1125-3_5
Cytokines in the treatment of fungal infections
Kullberg, B. J., & Wout, J. W. V. ’. (1994) · Springer eBooks · doi:10.1007/978-94-011-0233-9_7
Proton Pump Inhibitors and Risk of Infection: Is Suppression of Immune Defence Molecules to Blame?
Ghebre, Y. T. (2021) · touchREVIEWS in Respiratory & Pulmonary Diseases · doi:10.17925/usprd.2021.6.1.3
VARIABILIDADE DA FREQUÊNCIA CARDÍACA
Rubini, E. D. C. (2022) · Brazilian Journals Editora eBooks · doi:10.35587/brj.ed.0001385
TÓPICOS ESPECIAIS: METABOLÔMICA
Borges, R. M. (2022) · Brazilian Journals Editora eBooks · doi:10.35587/brj.ed.0001387
ORIGEM DO OVERTRAINING: ESTRESSE OXIDATIVO
Coelho, W. S. (2022) · Brazilian Journals Editora eBooks · doi:10.35587/brj.ed.0001383
OVERTRAINING NO FISICULTURISMO
de Amorim, M. V. C. (2022) · Brazilian Journals Editora eBooks · doi:10.35587/brj.ed.0001380
PERIODIZAÇÃO E ESTRATÉGIAS DE TREINAMENTO
Pinto, E. C. D. S. (2022) · Brazilian Journals Editora eBooks · doi:10.35587/brj.ed.0001386
ORIGEM DO OVERTRAINING: SISTEMA IMUNE
Dutra, P. M. L., & Guimarães, T. T. (2022) · Brazilian Journals Editora eBooks · doi:10.35587/brj.ed.0001382
Experimental models in vaccine research: malaria and leishmaniasis
Teixeira, C. A., & Gomes, R. D. S. (2013) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2013005002460
Determination of IFN -γ and TNF -α levels in serum of patients with Cutaneous leishmaniasis
Taher, H. M., Mohammed, S. A., & Mahmood, A. R. (2020) · Tikrit Journal of Pure Science · doi:10.25130/tjps.v25i6.311
“The cytokine TNF-α can enhances Th1/IFN-γ reactions against Leishmania major infection [7], also, it was seen that IFN-γ and TNF-α have synergistic killing effects against Leishmania major infection by activation of macrophages to increasing in production of NO [8].”
BackgroundLukaszonek, J., Brown, N., Zenga, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.24.587740
Akira, S., Tanaka, T., & Kishimoto, T. (1998) · doi:10.1007/978-1-4757-2753-1_17
Cordelia, Goneril and the febrile response.
Mackowiak, P. A. (1997) · PubMed
Kumar, J., Jyotisha, Qureshi, R., et al. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.153591
Antisense Inhibition of Inducible Nitric Oxide Synthase Expression - Does it make Sense?
Hemmrich, K. (2005) · Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver
Metadata
- Authors
- Liew, F. Y., Li, Y., & Millott, S.
- Affiliations
- Wellcome Trust (GB)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-12
- Volume
- 145
- Issue
- 12
- Pages
- 4306-4310
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1739247159
- Cited by
- 522
- References
- 0
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 5 · 2023: 9 · 2022: 10 · 2021: 9 · 2020: 16 · 2019: 7 · 2018: 14 · 2017: 16 · 2016: 11 · 2015: 13 · 2014: 21 · 2013: 16 · 2012: 15
- FWCI
- 37.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Health Sciences › Medicine › Infectious Diseases › Leprosy Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- Leishmania major, cutaneous leishmaniasis, TNF-α, interferon-gamma, nitric oxide, macrophage activation, antileishmanial activity, L-NG-monomethylarginine, superoxide, cytokine synergy
- MeSH terms
- Animals, Arginine, Cytotoxicity, Immunologic, Drug Synergism, Hydrogen Peroxide, Immunity, Cellular, Interferon-gamma, Leishmania tropica, Leishmaniasis, Macrophages, Mice, Inbred CBA, Nitric Oxide, Nitrites, Superoxides, Tumor Necrosis Factor-alpha, omega-N-Methylarginine, Mice
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