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Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization.
Abstract
These studies address the hypothesis that Ag-bearing epidermal Langerhans cells migrate to the regional lymph node during contact sensitization and function as APC. Skin from C3H mice was grafted onto BALB/c nude mice, and 7 or 14 days later, the recipients were sensitized with FITC through the grafts. APC from lymph nodes draining the site of sensitization were capable of sensitizing C3H recipients to FITC. Because sensitization is MHC restricted, only cells reaching the lymph node from the grafted skin could have induced contact hypersensitivity in C3H mice. Examination of the FITC+ draining lymph node cells by immunofluorescence and immunoelectron microscopy demonstrated that all were Ia+, most were F4/80+, and some contained Birbeck granules. These studies demonstrate that Ia+, FITC+ cells from the skin, at least some of which are Langerhans cells, leave the skin after epicutaneous sensitization with FITC and participate in the initiation of the contact hypersensitivity response within the regional lymph node.
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Citations
Cited by
Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632
Zaitseva, M., Blauvelt, A., Lee, S., Lapham, C. K., Kiaus-Kovrun, V., Mostowski, H., Manischewitz, J., & Golding, H. (1997) · Nature Medicine · doi:10.1038/nm1297-1369 · Cited by 389
Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective
Park, B. K., Pirmohamed, M., & Kitteringham, N. R. (1998) · Chemical Research in Toxicology · doi:10.1021/tx980058f · Cited by 267
Autocrine/paracrine TGFβ1 is required for the development of epidermal Langerhans cells
Kaplan, D. H., Li, M. O., Jenison, M. C., Shlomchik, W. D., Flavell, R. A., & Shlomchik, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071401 · Cited by 254
MC1R and the response of melanocytes to ultraviolet radiation
Rouzaud, F., Kadekaro, A. L., Abdel-Malek, Z. A., & Hearing, V. J. (2005) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2004.09.014 · Cited by 173
Metadata
- Authors
- Kripke, M. L., Munn, C. G., Jeevan, A., Tang, J. M., & Bucana, C.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-11-01
- Volume
- 145
- Issue
- 9
- Pages
- 2833-2838
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1510470032
- Cited by
- 532
- References
- 0
- FWCI
- 30.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization. https://app.cochat.ai/papers/10.4049/jimmunol.145.9.2833
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- Kripke, M. L., Munn, C. G., Jeevan, A., Tang, J. M., & Bucana, C. (1990). Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization. The Journal of Immunology. https://doi.org/10.4049/jimmunol.145.9.2833
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
