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Structural comparison and chromosomal localization of the human and mouse IL-13 genes
Abstract
The genomic structure of the recently described cytokine IL-13 has been determined for both human and mouse genes. The nucleotide sequence of a 4.6-kb DNA segment of the human gene is described. The human IL-13 gene (IL13) occurs as a single copy in the haploid genome and maps to human chromosome 5. A 4.3-kb DNA fragment of the mouse IL-13 gene (IL13) has been sequenced and found to occur as a single copy, mapping to mouse chromosome 11. Intrachromosomal mapping studies revealed that both genes contain four exons and three introns and show a high degree of sequence identity throughout their length. Potential recognition sequences for transcription factors that are present in the 5’-flanking region and are conserved between both genes include IFN-responsive elements, binding sites for AP-1, AP-2 and AP-3, and NF-IL 6 site, and a TATA-like sequence. Both genes map to chromosomal locations adjacent to genes encoding other cytokines, including IL-3, GM-CSF, IL-5, and IL-4, suggesting that IL-13 is another member of this cytokine gene family that may have arisen by gene duplication.
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Citations
Cited by
Opal, S. M., & DePalo, V. A. (2000) · Chest · doi:10.1378/chest.117.4.1162 · Cited by 1,752
Zurawski, G., & de Vries, J. E. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90021-3 · Cited by 872
Postma, D. S., Bleecker, E. R., Amelung, P. J., Holroyd, K. J., Xu, J., Panhuysen, C. I. M., Meyers, D. A., & Levitt, R. C. (1995) · New England Journal of Medicine · doi:10.1056/nejm199510053331402 · Cited by 758
Das, J., Chen, C.-H., Yang, L., Cohn, L., Ray, P., & Ray, A. (2001) · Nature Immunology · doi:10.1038/83158 · Cited by 518
Hyperproliferation and Dysregulation ofIL-4 Expression in NF-ATp-Deficient Mice
Hodge, M. R., Ranger, A. M., de la Brousse, F. C., Hoey, T., Grusby, M. J., & Glimcher, L. H. (1996) · Immunity · doi:10.1016/s1074-7613(00)80253-8 · Cited by 444
Metadata
- Authors
- McKenzie, A. N., Li, X., Largaespada, D. A., Sato, A., Kaneda, A., Zurawski, S. M., Doyle, E. L., Milatovich, A., Francke, U., & Copeland, N. G.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-06
- Volume
- 150
- Issue
- 12
- Pages
- 5436-5444
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1630729294
- Cited by
- 166
- References
- 0
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- McKenzie, A. N., Li, X., Largaespada, D. A., Sato, A., Kaneda, A., Zurawski, S. M., Doyle, E. L., Milatovich, A., Francke, U., & Copeland, N. G. (1993). Structural comparison and chromosomal localization of the human and mouse IL-13 genes. The Journal of Immunology. https://doi.org/10.4049/jimmunol.150.12.5436
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