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Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-alpha, IL-6 and IL-8 release by human monocytes and alveolar macrophages
Abstract
CD14 has been reported to function as a receptor for bacterial LPS complexed with serum proteins, transducing an activation signal for TNF-alpha production. We found that the anti-CD14 mAb MEM-18 inhibited not only LPS-induced release of TNF-alpha, but also LPS-induced, TNF-alpha independent release of IL-6 and IL-8 by human monocytes and alveolar macrophages. Inhibitory effect of MEM-18 was detected both in the presence of human or bovine calf serum and under serum-free conditions. In contrast, MEM-18 did not block release of these cytokines induced by IL-1 beta, TNF-alpha, PMA, and zymosan. We conclude that CD14 is involved in LPS-induced release of TNF-alpha, IL-6, and IL-8 by monocytes and alveolar macrophages and that this receptor appears to be able to recognize LPS directly in the absence of serum.
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Cited by
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Schols, A. M., Buurman, W. A., Staal van den Brekel, A. J., Dentener, M. A., & Wouters, E. F. (1996) · Thorax · doi:10.1136/thx.51.8.819 · Cited by 522
Self-citationSanlioglu, S., Williams, C. M., Samavati, L., Butler, N. S., Wang, G., McCray, P. B., Ritchie, T. C., Hunninghake, G. W., Zandi, E., & Engelhardt, J. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102061200 · Cited by 395
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Self-citationPathophysiologic and Prognostic Role of Cytokines in Dengue Hemorrhagic Fever
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Metadata
- Authors
- Dentener, M. A., Bazil, V, Von Asmuth, E. J., Ceska, M., & Buurman, W. A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-04-01
- Volume
- 150
- Issue
- 7
- Pages
- 2885-2891
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1666992496
- Cited by
- 318
- References
- 0
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-alpha, IL-6 and IL-8 release by human monocytes and alveolar macrophages. https://app.cochat.ai/papers/10.4049/jimmunol.150.7.2885
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- Dentener, M. A., Bazil, V, Von Asmuth, E. J., Ceska, M., & Buurman, W. A. (1993). Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-alpha, IL-6 and IL-8 release by human monocytes and alveolar macrophages. The Journal of Immunology. https://doi.org/10.4049/jimmunol.150.7.2885
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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