Role of IL-1 and tumor necrosis factor in coxsackie virus-induced autoimmune myocarditis.
Abstract
We have previously reported that B10.A (H-2a) mice, which are resistant to the induction of postcoxsackievirus autoimmune myocarditis, become susceptible upon treatment with LPS, IL-1, or TNF. In this study, we show that the development of autoimmune myocarditis is associated with infiltration of the heart by inflammatory cells that secrete the cytokines IL-1 and TNF. Local secretion of these cytokines contributes to increased levels of IL-1 and TNF in the serum. Thus, local production of cytokines promotes the induction of this postinfectious autoimmune disease.
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Elevated circulating cytokines could increase myocarditis, as shown when recombinant TNFα, IL-1β, or IL-33 was administered in coxsackievirus B3 virus-only or autoimmune CVB3 animal models.
“In this context, elevated circulating cytokines could increase myocarditis as has been shown previously when recombinant TNF α (tumor necrosis factor-alpha), IL (interleukin)-1 β , or IL-33 was administered in coxsackievirus B3 (CVB3) virus-only or autoimmune CVB3 animal models.”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [41]
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The role of IL-1 in the pathogenesis of heart disease
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Fairweather, D., Yusung, S., Frisancho, S., Barrett, M., Gatewood, S., Steele, R., & Rose, N. R. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4731 · Cited by 229 · see citing works
Self-citationCOVID-19, Myocarditis and Pericarditis
Fairweather, D., Beetler, D. J., Di Florio, D. N., Musigk, N., Heidecker, B., & Cooper, L. T. (2023) · Circulation Research · doi:10.1161/circresaha.123.321878 · Cited by 181 · see citing works
Eriksson, U., Kurrer, M. O., Sonderegger, I., Iezzi, G., Tafuri, A., Hunziker, L., Suzuki, S., Bachmaier, K., Bingisser, R. M., Penninger, J. M., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021788 · Cited by 158 · see citing works
Myocarditis: Infection Versus Autoimmunity
Rose, N. R. (2009) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9339-z · Cited by 127 · see citing works
Self-citationMyocarditis: An Interleukin-1-Mediated Disease?
De Luca, G., Cavalli, G., Campochiaro, C., Tresoldi, M., & Dagna, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01335 · Cited by 79 · see citing works
Genetic control of autoimmune myocarditis mediated by myosin-specific antibodies
Kuan, A. P., Chamberlain, W., Malkiel, S., Lieu, H. D., Factor, S. M., Diamond, B., & Kotzin, B. L. (1999) · Immunogenetics · doi:10.1007/s002510050466 · Cited by 38 · see citing works
- Authors
- Lane, J. R., Neumann, D. A., Lafond-Walker, A., Herskowitz, A., & Rose, N. R.
- Affiliations
- Johns Hopkins University (US)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-08-01
- Volume
- 151
- Issue
- 3
- Pages
- 1682-1690
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1520272833
- Cited by
- 141
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 1 · 2012: 5
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-33878, R01HL033878)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- Coxsackie virus, interleukin-1, TNF-α, cytokines, B10.A mice, lipopolysaccharide, inflammatory cell infiltration, heart, autoimmunity
- MeSH terms
- Animals, Autoantibodies, Autoimmune Diseases, Coxsackievirus Infections, Enterovirus, Immunoglobulin G, Interleukin-1, Leukocytes, Lipopolysaccharides, Mice, Inbred Strains, Myocarditis, Myofibrils, Sarcolemma, Tumor Necrosis Factor-alpha, Cytokines, Mice
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