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Effects of CD45 on NF-kappa B. Implications for replication of HIV-1.
Abstract
Increased levels of replication of the HIV type 1 are observed after the activation of infected T cells through the TCR. However, anti-CD45 antibodies inhibit these effects in cells from infected individuals. In this study, we examined interrelationships between CD45 and HIV-1 further. We measured effects on the HIV-1 LTR in T cell lines that were stimulated with antibodies against CD45 and in those that lacked the expression of CD45 on their surfaces. First, anti-CD45 antibodies did not affect basal but decreased activated levels of expression from the HIV-1 LTR. Second, T cells, which lack CD45 and cannot signal via the TCR, supported higher levels of viral replication and gene expression. This was due to the presence of active NF-kappa B complexes in the nucleus of CD45- T cells. Additionally, infected T cells displayed lower levels of CD45 on their surfaces. Thus, CD45 plays an active role in the physiology of T cells and in the replication of HIV-1.
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“CD45 has also been shown to down-regulate NF-κB, an important mediator of pro-inflammatory cytokines [38].”
From miR-155 induction in microglial cells suppresses Japanese encephalitis virus replication and negatively modulates innate immune responses (2014) · cites this paper as [38]
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Muratori, C., Cavallin, L. E., Krätzel, K., Tinari, A., De Milito, A., Fais, S., D'Aloja, P., Federico, M., Vullo, V., Fomina, A., et al. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.06.009 · Cited by 164
Self-citationPareek, S., Roy, S., Kumari, B., Jain, P., Banerjee, A., & Vrati, S. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-97 · Cited by 121
Metadata
- Authors
- Baur, A., Garber, S., & Peterlin, B. M.
- Affiliations
- Howard Hughes Medical Institute and Departments of Medicine, Microbiology and Immunology, University of California at San Francisco , San Francisco, CA 94143-0724
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-02-01
- Volume
- 152
- Issue
- 3
- Pages
- 976-983
- ISSN
- 0022-1767
- 1550-6606
- Cited by
- 16
- References
- 0
- Language
- en
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- CoChat. (2026). Citation check: Effects of CD45 on NF-kappa B. Implications for replication of HIV-1. https://app.cochat.ai/papers/10.4049/jimmunol.152.3.976
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- Baur, A., Garber, S., & Peterlin, B. M. (1994). Effects of CD45 on NF-kappa B. Implications for replication of HIV-1. The Journal of Immunology. https://doi.org/10.4049/jimmunol.152.3.976
