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IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection
Abstract
IL-12, a cytokine produced by macrophages and B cells, has recently been found to exert pleiotropic effects on the immune system. When BALB/c mice, a strain highly susceptible to virulent Mycobacterium tuberculosis infection, were given IL-12 at the initiation of infection with M. tuberculosis, their mean survival time doubled from 58 to 112 days. IL-12-treated mice had diminished bacterial burdens, whereas treatment with exogenous IFN-γ had no effect on survival or bacterial burden. IL-12 treatment also delayed lung pathology in BALB/c mice. In contrast with the findings in the BALB/c model, IL-12 did not increase survival of M. tuberculosis-infected gko mice, transgenic mice in which the IFN-γ gene has been disrupted, indicating that IL-12 does not induce protection against tuberculosis in mice in the absence of IFN-γ.
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Citations
Cited by
Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity
Trinchieri, G. (1998) · Advances in Immunology · doi:10.1016/s0065-2776(08)60387-9 · Cited by 760
Bafica, A., Scanga, C. A., Feng, C. G., Leifer, C., Cheever, A., & Sher, A. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051782 · Cited by 601
Human macrophage activation programs induced by bacterial pathogens
Nau, G. J., Richmond, J. F. L., Schlesinger, A., Jennings, E. G., Lander, E. S., & Young, R. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022649799 · Cited by 568
A mAb recognizing a surface antigen of Mycobacterium tuberculosis enhances host survival
Teitelbaum, R., Glatman-Freedman, A., Chen, B., Robbins, J. B., Unanue, E., Casadevall, A., & Bloom, B. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15688 · Cited by 275
Self-citationAvau, A., Mitera, T., Put, S., Put, K., Brisse, E., Filtjens, J., Uyttenhove, C., Van Snick, J., Liston, A., Leclercq, G., et al. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38359 · Cited by 90
Metadata
- Authors
- Flynn, J. L., Goldstein, M. M., Triebold, K. J., Sypek, J., Wolf, S., & Bloom, B. R.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-09-01
- Volume
- 155
- Issue
- 5
- Pages
- 2515-2524
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1506273507
- Cited by
- 324
- References
- 0
- FWCI
- 17.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Flynn, J. L., Goldstein, M. M., Triebold, K. J., Sypek, J., Wolf, S., & Bloom, B. R. (1995). IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection. The Journal of Immunology. https://doi.org/10.4049/jimmunol.155.5.2515
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
