Cited by 114Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

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B7-1 but not B7-2 efficiently costimulates CD8+ T lymphocytes in the P815 tumor system in vitro

Gajewski, T F·1996·The Journal of Immunology

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Abstract

We recently have developed a method to generate primary P815-specific CTL in vitro from normal syngeneic splenocytes by employing transfection of B7-1 combined with exogenous IL-12 and IL-6. Surprisingly, when the homologous costimulator molecule B7-2 was substituted for B7-1 in this system, no specific CTL activity was obtained. Similarly, B7-1- but not B7-2-transfected P815 cells generated alloantigen-specific CTL activity from C57BL/6, accessory cell- and CD4(+)-depleted splenocytes, and costimulated proliferation of CD8+ lymphocytes in the presence of low doses of anti-CD3 mAb. In all systems, combined expression of both B7-1 and B7-2 costimulated as effectively as B7-1 alone, arguing against delivery of a dominant negative signal by B7-2. Proliferation of allogeneic, CD4(+)-depleted splenocytes in response to P815 cells, which relies on costimulation by normal accessory cells, was inhibited by anti-B7-1 but not anti-B7-2 mAbs. Finally, indirect evidence suggested a higher avidity of B7-1+ cells than B7-2+ cells for CTLA4. Thus, at least in the context of primary stimulation by irradiated P815 transfectants, B7-1 appears to be superior to B7-2 at costimulation of CD8+ T lymphocytes.

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Crossref · 10.4049/jimmunol.156.2.465

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Authors: Gajewski, T. F.
Affiliations: Ludwig Cancer Research (BE)
Corresponding author: Gajewski, T F
ORCID: Gajewski, T F
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1996-01
Volume: 156
Issue: 2
Pages: 465-472
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.156.2.465
OpenAlex: W1946324007
Cited by: 114
References: 0
Citations by year: 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1 · 2012: 2
FWCI: 7.40
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: CD80, CD86, costimulation, CD8+ T cells, cytotoxic T lymphocytes, P815 tumor cells, CTLA-4, IL-12, interleukin-6, T cell proliferation, accessory cells
MeSH terms: Abatacept, Animals, Antibodies, Monoclonal, Antigens, Differentiation, Base Sequence, Cells, Cultured, Cytotoxicity, Immunologic, Female, Interleukin-2, Leukemia L1210, Lymphocyte Culture Test, Mixed, Lymphocyte Activation, Membrane Glycoproteins, Mice, Inbred C57BL, Mice, Inbred DBA, Molecular Sequence Data, Recombinant Proteins, Mast-Cell Sarcoma, Specific Pathogen-Free Organisms, Spleen, T-Lymphocytes, Cytotoxic, Transfection, Tumor Cells, Cultured, Signal Transduction, CD4-Positive T-Lymphocytes, Antigens, CD, Interleukin-6, Muromonab-CD3, B7-1 Antigen, Interleukin-12, Immunoconjugates, Mice, B7-2 Antigen, CTLA-4 Antigen

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B7-1 but not B7-2 efficiently costimulates CD8+ T lymphocytes in the P815 tumor system in vitro

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