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Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3α and MIP-3beta
Abstract
An increasing number of proinflammatory peptides, known as chemokines, are constantly being described and characterized. Because of their proven biologic functions in allergy, AIDS and, in general, inflammatory processes, these proteins have recently gained more attention. In this study we report the identification through bioinformatics of two new human chemokines: MIP-3α and MIP-3beta. Both of them belong to the β- or CC chemokine family. Expression studies indicate that MIP-3α is predominantly expressed in lymph nodes, appendix, PBL, fetal liver, fetal lung and several cell lines. However, MIP-3beta expression is restricted to lymph nodes, thymus and appendix. Interestingly enough, both chemokines manifested a pattern of expression strongly regulated by IL-10. In contrast with other CC chemokines, MIP-3beta maps to chromosome 9. Here we show the importance of bioinformatics to discover new molecules with possible therapeutic effects and regulatory functions.
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Citations
Cited by
Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
The Biology of Chemokines and their Receptors
Rossi, D., & Zlotnik, A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.217 · Cited by 2,410
Self-citationReboldi, A., Coisne, C., Baumjohann, D., Benvenuto, F., Bottinelli, D., Lira, S., Uccelli, A., Lanzavecchia, A., Engelhardt, B., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1716 · Cited by 1,206
Legler, D. F., Loetscher, M., Roos, R. S., Clark-Lewis, I., Baggiolini, M., & Moser, B. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.4.655 · Cited by 837
Ngo, V. N., Korner, H., Gunn, M. D., Schmidt, K. N., Sean Riminton, D., Cooper, M. D., Browning, J. L., Sedgwick, J. D., & Cyster, J. G. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.2.403 · Cited by 553
Metadata
- Authors
- Rossi, D. L., Vicari, A. P., Franz-Bacon, K., McClanahan, T. K., & Zlotnik, A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-02-01
- Volume
- 158
- Issue
- 3
- Pages
- 1033-1036
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1539161723
- Cited by
- 312
- References
- 0
- FWCI
- 15.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3α and MIP-3beta. https://app.cochat.ai/papers/10.4049/jimmunol.158.3.1033
- The paper
- Rossi, D. L., Vicari, A. P., Franz-Bacon, K., McClanahan, T. K., & Zlotnik, A. (1997). Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3α and MIP-3beta. The Journal of Immunology. https://doi.org/10.4049/jimmunol.158.3.1033
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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