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Surfactant protein A-deficient mice are susceptible to group B streptococcal infection
Abstract
To determine the role of surfactant protein A (SP-A) in host defense, the murine SP-A locus was targeted by homologous recombination to produce mice lacking SP-A. SP-A -/- and control mice were infected with group B streptococcus (GBS) by intratracheal instillation. Pulmonary infiltration 6 and 24 h following infection was more severe in SP-A -/- than in control mice, and was associated with increased numbers of GBS in lung homogenates. Dissemination of GBS to the spleen was observed more frequently in SP-A -/- mice. Pulmonary infiltration with macrophages was similar in both groups; however, the number of bacteria associated with alveolar macrophages was decreased in the SP-A-deficient mice. There was no detectable compensatory increase in surfactant protein D, the other known pulmonary collectin, in response to GBS instillation. SP-A plays an important role in vivo, enhancing clearance of GBS from the lung and inhibiting systemic dissemination of the organism.
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Cited by
Collectins and Ficolins: Humoral Lectins of the Innate Immune Defense
Holmskov, U., Thiel, S., & Jensenius, J. C. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.140954 · Cited by 762
Distinct Effects of Surfactant Protein A or D Deficiency During Bacterial Infection on the Lung
LeVine, A. M., Whitsett, J. A., Gwozdz, J. A., Richardson, T. R., Fisher, J. H., Burhans, M. S., & Korfhagen, T. R. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.7.3934 · Cited by 352
Self-citationThe extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens
He, Y.-W., Li, H., Zhang, J., Hsu, C.-L., Lin, E., Zhang, N., Guo, J., Forbush, K. A., & Bevan, M. J. (2004) · Nature Immunology · doi:10.1038/ni1021 · Cited by 171
McKenzie, Z., Kendall, M., Mackay, R.-M., Whitwell, H., Elgy, C., Ding, P., Mahajan, S., Morgan, C., Griffiths, M., Clark, H., et al. (2015) · Nanotoxicology · doi:10.3109/17435390.2014.992487 · Cited by 31
Metadata
- Authors
- LeVine, A. M., Bruno, M. D., Huelsman, K. M., Ross, G. F., Whitsett, J. A., & Korfhagen, T. R.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-05-01
- Volume
- 158
- Issue
- 9
- Pages
- 4336-4340
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1595806145
- Cited by
- 342
- References
- 0
- FWCI
- 45.21
- Type
- journal article
- Language
- en
- Open access
- closed
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