The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Partially Modified Retro-Inverso Pseudopeptide Modulates the Cytokine Profile of CTL Specific for an Influenza Virus Epitope
Abstract
There is considerable evidence that peptides corresponding to MHC class I-restricted epitopes can be used as immunogens or immunomodulators. Pseudopeptides containing isosteric replacements of the amide bond provide more stable analogues, which may even have enhanced biologic activity. But there have been very few studies on the use of pseudopeptides to initiate or modulate the cellular immune response. This study describes the immunogenicity of a partially modified retro-inverso pseudopeptide of an influenza virus epitope and shows that this pseudopeptide modulates the cytokine profile expressed by CD8+CTL generated from primed precursors. Moreover, the pseudopeptide is much more efficient at low concentration than the wild-type epitope to stimulate IFN-γ secretion by CD8+ T effector cells. These results are analyzed with reference to changes in the conformation of the MHC molecule/peptide complex deduced from molecular modeling. The findings support the idea that partially modified retro-inverso analogues can be used as altered peptide ligands to enhance the stimulation of natural epitope-specific CTL and to modify their functional properties. Hence, pseudopeptide ligands might be promising tools for use in immunotherapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Barth, R. J., Mulé, J. J., Spiess, P. J., & Rosenberg, S. A. (1991) · The Journal of experimental medicine · doi:10.1084/jem.173.3.647 · Cited by 402
Research works printed but not linked: 30
- 1995, Annu. Rev. Immunol., 587
- 1987, Nature, 506
- 1995, Immunol. Today, 223
- 1996, Annu. Rev. Immunol., 259
- 1996, Annu. Rev. Immunol., 1
- 1992, Adv. Drug Res., 127
- 1997, Proc. Natl. Acad. Sci. USA, 12545
- 1995, J. Biol. Chem., 11921
- 1996, J. Biol. Chem., 33218
- 1994, Proc. Natl. Acad. Sci. USA, 9765
- 1995, J. Biol. Chem., 30422
- 1997, J. Immunol., 3230
- 1996, J. Med. Chem., 2030
- 1994, Eur. J. Immunol., 777
- 1990, Eur. J. Immunol., 2171
- 1987, Nature, 881
- 1996, Cytokine, 32
- 1997, J. Exp. Med., 859
- 1993, Cell, 693
- 1993, Acc. Chem. Res., 266
- 1992, J. Immunol., 2580
- 1992, Eur. J. Biochem., 101
- 1996, Curr. Opin. Immunol., 478
- 1991, J. Exp. Med., 647
- 1996, J. Exp. Med., 149
- 1995, Science, 515
- 1994, Proc. Natl. Acad. Sci. USA, 12862
- 1996, Immunity, 53
- 1989, Cold Spring Harbor Symp. Quant. Biol., 657
- 1994, Immunity, 563
Cited by
Webb, A. I., Dunstone, M. A., Williamson, N. A., Price, J. D., de Kauwe, A., Chen, W., Oakley, A., Perlmutter, P., McCluskey, J., Aguilar, M.-I., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.6.3810 · Cited by 57
Unlocking the Potential of Retro-Inverso (RI) Peptides as Future Drug Candidates
Al Musaimi, O. (2024) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-024-10639-1 · Cited by 18
Metadata
- Authors
- Ostankovitch, M., Guichard, G., Connan, F., Muller, S., Chaboissier, A., Hoebeke, J., Choppin, J., Briand, J.-P., & Guillet, J.-G.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-07-01
- Volume
- 161
- Issue
- 1
- Pages
- 200-208
- ISSN
- 0022-1767
- 1550-6606
- Cited by
- 27
- References
- 1
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Partially Modified Retro-Inverso Pseudopeptide Modulates the Cytokine Profile of CTL Specific for an Influenza Virus Epitope. https://app.cochat.ai/papers/10.4049/jimmunol.161.1.200
- The paper
- Ostankovitch, M., Guichard, G., Connan, F., Muller, S., Chaboissier, A., Hoebeke, J., Choppin, J., Briand, J.-P., & Guillet, J.-G. (1998). A Partially Modified Retro-Inverso Pseudopeptide Modulates the Cytokine Profile of CTL Specific for an Influenza Virus Epitope. The Journal of Immunology. https://doi.org/10.4049/jimmunol.161.1.200
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
