OPG/FDCR-1, a TNF receptor family member, is expressed in lymphoid cells and is up-regulated by ligating CD40.
Abstract
We have cloned a TNFR family member from a follicular dendritic cell (FDC)-like cell line, FDC-1. This molecule, FDC-derived receptor-1 (FDCR-1), is identical to osteoprotegerin (OPG), a soluble cytokine that regulates osteoclast differentiation. Recently, OPG/FDCR-1 has been characterized as a second receptor for receptor activator of NF-κB ligand (RANKL)/TNF-related activation-induced cytokine (TRANCE), a primarily T-cell restricted TNF family member that augments dendritic cell (DC) function. In this report, we demonstrate that OPG/FDCR-1 is membrane bound on the surface of transfected baby hamster kidney (BHK) and untransfected FDC-1 cells. We also found a restricted OPG/FDCR-1 expression pattern in lymphoid cells, specifically in B cells, DCs and FDC-enriched fractions, which in B cells and DCs is up-regulated by CD40 stimulation. Because OPG/FDCR-1 shares some properties with RANK, the first RANKL/TRANCE receptor, we discuss how the balance between RANK and OPG/FDCR-1 expression could influence immune responses and, ultimately, germinal center formation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
RANKL is expressed by T cells, RANK by dendritic cells, and OPG by B lymphocytes and dendritic cells.
“Within the developed immune system, RANKL is expressed by T cells (42), RANK is expressed by dendritic cells (49), and OPG is expressed by B lymphocytes and dendritic cells (4,70).”
From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [70]
The citation lists haven’t been fetched yet
References 60 · Cited by 307
- Authors
- Yun, T. J., Chaudhary, P. M., Shu, G. L., Frazer, J. K., Ewings, M. K., Schwartz, S. M., Pascual, V., Hood, L. E., & Clark3, E. A.
- Affiliations
- University of Washington (US)
- The University of Texas Southwestern Medical Center (US)
- Department of Immunology, University of Washington , Seattle, WA 98195
- ORCID
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-12-01
- Volume
- 161
- Issue
- 11
- Pages
- 6113-6121
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1545561369
- Cited by
- 307
- References
- 60
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 10 · 2023: 7 · 2022: 2 · 2021: 8 · 2020: 9 · 2019: 14 · 2018: 9 · 2017: 11 · 2016: 19 · 2015: 10 · 2014: 14 · 2013: 12 · 2012: 12
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM-37905, R01GM037905)
- National Institute of Dental and Craniofacial Research (P50DE008229, DE 0 8229)
- National Center for Research Resources (RR00166, P51RR000166)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- osteoprotegerin, TNF receptor superfamily, CD40 stimulation, follicular dendritic cells, dendritic cells, B cells, RANK, cell surface receptors, lymphoid cells, germinal center formation, osteoclastogenesis
- MeSH terms
- Animals, Cell Line, Cell Membrane, Dendritic Cells, Glycoproteins, Cricetinae, Humans, Kidney, Lymphoid Tissue, Organ Specificity, Solubility, Up-Regulation, Receptors, Tumor Necrosis Factor, Receptors, Cytoplasmic and Nuclear, CD40 Antigens, Osteoprotegerin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
