The DOI matches its Crossref record.
Cutting Edge: Selective Deamidation by Tissue Transglutaminase Strongly Enhances Gliadin-Specific T Cell Reactivity
Abstract
Celiac disease (CD) is caused by gluten ingestion in susceptible individuals. Tissue transglutaminase (tTG)-specific Abs are characteristic of CD, and increased tTG activity has been observed in the jejunal biopsies of patients. Here we demonstrate that tTG selectively deamidates gluten peptides, which results in strongly enhanced T cell-stimulatory activity. To our knowledge, this is the first example of an enzymatic modification of a food protein that affects T cell recognition. Moreover, these modifications may lead to the amplification of gluten-specific T cell responses in the gut and consequently may be important for the development of CD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Coeliac disease: dissecting a complex inflammatory disorder
Sollid, L. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri885 · Cited by 964
Di Sabatino, A., & Corazza, G. R. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60254-3 · Cited by 555
Gluten sensitivity: from gut to brain
Hadjivassiliou, M., Sanders, D. S., Grünewald, R. A., Woodroofe, N., Boscolo, S., & Aeschlimann, D. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70290-x · Cited by 404
Celiac disease: pathogenesis of a model immunogenetic disease
Kagnoff, M. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30253 · Cited by 386
Specificity of Tissue Transglutaminase Explains Cereal Toxicity in Celiac Disease
Vader, L. W., de Ru, A., van der Wal, Y., Kooy, Y. M. C., Benckhuijsen, W., Mearin, M. L., Drijfhout, J. W., van Veelen, P., & Koning, F. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20012028 · Cited by 357
Self-citation
Metadata
- Authors
- van de Wal, Y., Kooy, Y., van Veelen, P., Peña, S., Mearin, L., Papadopoulos, G., & Koning, F.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-08
- Volume
- 161
- Issue
- 4
- Pages
- 1585-1588
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W4313333826
- Cited by
- 432
- References
- 0
- FWCI
- 14.27
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cutting Edge: Selective Deamidation by Tissue Transglutaminase Strongly Enhances Gliadin-Specific T Cell Reactivity. https://app.cochat.ai/papers/10.4049/jimmunol.161.4.1585
- The paper
- van de Wal, Y., Kooy, Y., van Veelen, P., Peña, S., Mearin, L., Papadopoulos, G., & Koning, F. (1998). Cutting Edge: Selective Deamidation by Tissue Transglutaminase Strongly Enhances Gliadin-Specific T Cell Reactivity. The Journal of Immunology. https://doi.org/10.4049/jimmunol.161.4.1585
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
