The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
IL-18 Is Produced by Articular Chondrocytes and Induces Proinflammatory and Catabolic Responses
Abstract
IL-18, a cytokine originally identified as IFN-γ-inducing factor, is a member of the IL-1 family of proteins. Because IL-1α and IL-1β are important mediators in the pathogenesis of arthritis, the present study addresses the expression of IL-18 and its role in regulating in articular chondrocytes. IL-18 mRNA was induced by IL-1β in chondrocytes. Chondrocytes produced the IL-18 precursor and in response to IL-1 stimulation secreted the mature form of IL-18. Studies on IL-18 effects on chondrocytes showed that it inhibits TGF-β-induced proliferation and enhances nitric oxide production. IL-18 stimulated the expression of several genes in normal human articular chondrocytes including inducible nitric oxide synthase, inducible cyclooxygenase, IL-6, and stromelysin. Gene expression was associated with the synthesis of the corresponding proteins. Treatment of normal human articular cartilage with IL-18 increased the release of glycosaminoglycans. These finding identify IL-18 as a cytokine that regulates chondrocyte responses and contributes to cartilage degradation.
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Udagawa, N., Horwood, N. J., Elliott, J., Mackay, A., Owens, J., Okamura, H., Kurimoto, M., Chambers, T. J., Martin, T. J., & Gillespie, M. T. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.6.1005 · Cited by 378
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Kapoor, M., Martel-Pelletier, J., Lajeunesse, D., Pelletier, J.-P., & Fahmi, H. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.196 · Cited by 2,778
The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis
Wojdasiewicz, P., Poniatowski, Ł. A., & Szukiewicz, D. (2014) · Mediators of Inflammation · doi:10.1155/2014/561459 · Cited by 1,608
Interleukin-18 Regulates Both Th1 and Th2 Responses
Nakanishi, K., Yoshimoto, T., Tsutsui, H., & Okamura, H. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.423 · Cited by 1,315
Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations
Sokolove, J., & Lepus, C. M. (2013) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x12467868 · Cited by 1,100
Zaki, M. H., Boyd, K. L., Vogel, P., Kastan, M. B., Lamkanfi, M., & Kanneganti, T.-D. (2010) · Immunity · doi:10.1016/j.immuni.2010.03.003 · Cited by 989
Metadata
- Authors
- Olee, T., Hashimoto, S., Quach, J., & Lotz, M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-01
- Volume
- 162
- Issue
- 2
- Pages
- 1096-1100
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1571519341
- Cited by
- 243
- References
- 1
- FWCI
- 14.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: IL-18 Is Produced by Articular Chondrocytes and Induces Proinflammatory and Catabolic Responses. https://app.cochat.ai/papers/10.4049/jimmunol.162.2.1096
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- Olee, T., Hashimoto, S., Quach, J., & Lotz, M. (1999). IL-18 Is Produced by Articular Chondrocytes and Induces Proinflammatory and Catabolic Responses. The Journal of Immunology. https://doi.org/10.4049/jimmunol.162.2.1096
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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