The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Neutrophil Recruitment by Human IL-17 Via C-X-C Chemokine Release in the Airways
Open accessAbstract
IL-17 is a recently discovered cytokine that can be released from activated human CD4+ T lymphocytes. This study assessed the proinflammatory effects of human (h) IL-17 in the airways. In vitro, hIL-17 increased the release of IL-8 in human bronchial epithelial and venous endothelial cells, in a time- and concentration-dependent fashion. This effect of hIL-17 was inhibited by cotreatment with an anti-hIL-17 Ab and was potentiated by hTNF-α. In addition, hIL-17 increased the expression of hIL-8 mRNA in bronchial epithelial cells. Conditioned medium from hIL-17-treated bronchial epithelial cells increased human neutrophil migration in vitro. This effect was blocked by an anti-hIL-8 Ab. In vivo, intratracheal instillation of hIL-17 selectively recruited neutrophils into rat airways. This recruitment of neutrophils into the airways was inhibited by an anti-hIL-17 Ab and accompanied by increased levels of rat macrophage inflammatory protein-2 (rMIP-2) in bronchoalveolar lavage (BAL) fluid. The BAL neutrophilia was also blocked by an anti-rMIP-2 Ab. The effect of hIL-17 on the release of hIL-8 and rMIP-2 was also inhibited by glucocorticoids, in vitro and in vivo, respectively. These data demonstrate that hIL-17 can specifically and selectively recruit neutrophils into the airways via the release of C-X-C chemokines from bronchial epithelial cells and suggest a novel mechanism linking the activation of T-lymphocytes to recruitment of neutrophils into the airways.
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Cites
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J., Garrone, P., Garcia, E., Saeland, S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2593 · Cited by 1,526 · cited 2×
“The notion that hIL-17 can recruit neutrophils via C-X-C chemokine release is consistent with the recent in vitro finding that hIL-17 releases hIL-8 from fibroblasts (14).”
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Cited by
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541
Interleukin-17 Family Members and Inflammation
Kolls, J. K., & Lindén, A. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.018 · Cited by 2,372
IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6
Yen, D., Cheung, J., Scheerens, H., Poulet, F., McClanahan, T., Mckenzie, B., Kleinschek, M. A., Owyang, A., Mattson, J., Blumenschein, W., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci21404 · Cited by 1,542
Afzali, B., Lombardi, G., Lechler, R. I., & Lord, G. M. (2007) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2007.03356.x · Cited by 762
Metadata
- Authors
- Laan, M., Cui, Z.-H., Hoshino, H., Lötvall, J., Sjöstrand, M., Gruenert, D. C., Skoogh, B.-E., & Lindén, A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-02
- Volume
- 162
- Issue
- 4
- Pages
- 2347-2352
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1840746127
- Cited by
- 880
- References
- 1
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Neutrophil Recruitment by Human IL-17 Via C-X-C Chemokine Release in the Airways. https://app.cochat.ai/papers/10.4049/jimmunol.162.4.2347
- The paper
- Laan, M., Cui, Z.-H., Hoshino, H., Lötvall, J., Sjöstrand, M., Gruenert, D. C., Skoogh, B.-E., & Lindén, A. (1999). Neutrophil Recruitment by Human IL-17 Via C-X-C Chemokine Release in the Airways. The Journal of Immunology. https://doi.org/10.4049/jimmunol.162.4.2347
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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