The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
The Antiinflammatory Sesquiterpene Lactone Parthenolide Inhibits NF-κB by Targeting the IκB Kinase Complex
Abstract
The transcription factor NF-κB is a key regulator of the cellular inflammatory and immune response. Therefore, components of the NF-κB-activating signaling pathways are frequent targets for antiinflammatory agents. This study shows that the sesquiterpene lactone parthenolide inhibits a common step in NF-κB activation by preventing the TNF-α-induced induction of IκB kinase (IKK) and IKKβ, without affecting the activation of p38 and c-Jun N-terminal kinase. Parthenolide impairs NF-κB-dependent transcription triggered by expression of TNFR-associated factor-2, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEKK1), and NF-κB-inducing kinase. This compound also prevents activation of both IKKs and DNA binding of NF-κB induced by MEKK and NF-κB-inducing kinase. Parthenolide targets a component of the IκB kinase complex without directly inhibiting IKKα, IKKβ, or MEKK1. Therefore, this sesquiterpene lactone could serve as a lead compound for the development of antiinflammatory remedies and is suitable as a molecular tool, allowing the dissection of TNF-α-derived signaling pathways leading to the activation of NF-κB, c-Jun N-terminal kinase, and p38.
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Cites
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Metadata
- Authors
- Hehner, S. P., Hofmann, T. G., Dröge, W., & Schmitz, M. L.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-11
- Volume
- 163
- Issue
- 10
- Pages
- 5617-5623
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W4313347901
- Cited by
- 355
- References
- 37
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hehner, S. P., Hofmann, T. G., Dröge, W., & Schmitz, M. L. (1999). The Antiinflammatory Sesquiterpene Lactone Parthenolide Inhibits NF-κB by Targeting the IκB Kinase Complex. The Journal of Immunology. https://doi.org/10.4049/jimmunol.163.10.5617
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