The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cutting Edge: Cytolytic Effector Function in Human Circulating CD8+ T Cells Closely Correlates with CD56 Surface Expression
Open accessAbstract
Recent data suggest that human effector CD8+ T cells express a distinct CD27−CD45RAhigh (CD57+CD28−CD11ahigh) phenotype. Here, we propose that CTL effector function correlates better with CD56 (neuronal cell adhesion molecule (NCAM)) surface expression. CD56 was absent on cord blood CD8+ T cells, but was expressed by 4–30% of freshly isolated circulating CD8+ T cells from 15 adults. Dramatic oligoclonal expansions in 3/3 individuals were confined to the CD56+ subset of CD8+ T cells. The CD56+ subset generally contained high amounts of intracellular perforin and granzyme B. Finally, direct cytolytic capacity was closely restricted to the CD56+(CD45RAhigh) cells, better than to CD27−CD45RAhigh cells in 5/5 individuals analyzed. Thus, the phenotype corresponding to the circulating effector CD8+ T cell pool may be simplified and more precisely defined by the use of just two surface markers: CD8 and CD56.
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Immunological memory and protective immunity: understanding their relation
Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775 · cited 1×
“Some cells differentiate into so-called memory cells that are not directly cytolytic but can be rapidly reactivated upon exposure to Ag (3).”
BackgroundPosnett, D. N., Edinger, J. W., Manavalan, J. S., Irwin, C., & Marodon, G. (1999) · International Immunology · doi:10.1093/intimm/11.2.229 · Cited by 202
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Metadata
- Authors
- Pittet, M. J., Speiser, D. E., Valmori, D., Cerottini, J.-C., & Romero, P.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-02-01
- Volume
- 164
- Issue
- 3
- Pages
- 1148-1152
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1594345612
- Cited by
- 252
- References
- 2
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Pittet, M. J., Speiser, D. E., Valmori, D., Cerottini, J.-C., & Romero, P. (2000). Cutting Edge: Cytolytic Effector Function in Human Circulating CD8+ T Cells Closely Correlates with CD56 Surface Expression. The Journal of Immunology. https://doi.org/10.4049/jimmunol.164.3.1148
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