The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Immortalization of Human CD8+ T Cell Clones by Ectopic Expression of Telomerase Reverse Transcriptase
Open accessAbstract
Replicative senescence of T cells is correlated with erosion of telomere ends. Telomerase plays a key role in maintaining telomere length. Therefore, it is thought that telomerase regulates the life span of T cells. To test this hypothesis, we have over-expressed human telomerase reverse transcriptase in human CD8+ T cells. Ectopic expression of human telomerase reverse transcriptase led to immortalization of these T cells, without altering the phenotype and without loss of specificity or functionality. As the T cells remained dependent on cytokines and Ag stimulation for their in vitro expansion, we conclude that immortalization was achieved without malignant transformation.
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Cites
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Cited by
Switching and Signaling at the Telomere
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Autoimmune Destruction of Skin Melanocytes by Perilesional T Cells from Vitiligo Patients
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Aging of the Immune System: How Much Can the Adaptive Immune System Adapt?
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Metadata
- Authors
- Hooijberg, E., Ruizendaal, J. J., Snijders, P. J. F., Kueter, E. W. M., Walboomers, J. M. M., & Spits, H.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-10
- Volume
- 165
- Issue
- 8
- Pages
- 4239-4245
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2139137777
- Cited by
- 171
- References
- 10
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Immortalization of Human CD8+ T Cell Clones by Ectopic Expression of Telomerase Reverse Transcriptase. https://app.cochat.ai/papers/10.4049/jimmunol.165.8.4239
- The paper
- Hooijberg, E., Ruizendaal, J. J., Snijders, P. J. F., Kueter, E. W. M., Walboomers, J. M. M., & Spits, H. (2000). Immortalization of Human CD8+ T Cell Clones by Ectopic Expression of Telomerase Reverse Transcriptase. The Journal of Immunology. https://doi.org/10.4049/jimmunol.165.8.4239
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
