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Cutting Edge: A Role for B Lymphocyte Stimulator in Systemic Lupus Erythematosus
Open accessAbstract
Increased levels of B lymphocyte stimulator (BLyS) are associated with systemic autoimmunity in animal models of spontaneous autoimmune disease, and transgenic animals expressing BLyS develop typical autoimmune disease. Here, we demonstrate significant elevations of BLyS in the patients with systemic lupus erythematosus (SLE). The BLyS isolated from the sera of SLE patients had the same m.w. as the natural soluble form and was able to stimulate B cell activation in vitro. Increased BLyS in SLE patients was partially associated with higher levels of anti-dsDNA Ab of the IgG, IgM, and IgA classes, but not associated with the disease activity. Our results suggest that BLyS may be a useful marker for early activation of an autoimmune diathesis and likely plays a critical role in triggering activation of self-Ag-driven autoimmune B cells in human SLE. BLyS may provide an effective therapeutic target in systemic autoimmunity.
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Citations
Cited by
Cheema, G. S., Roschke, V., Hilbert, D. M., & Stohl, W. (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200106)44:6<1313::aid-art223>3.0.co;2-s · Cited by 802
Self-citationMoreaux, J., Legouffe, E., Jourdan, E., Quittet, P., Rème, T., Lugagne, C., Moine, P., Rossi, J.-F., Klein, B., & Tarte, K. (2004) · Blood · doi:10.1182/blood-2003-06-1984 · Cited by 558
The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjögren's syndrome
Mariette, X., Roux, S., Zhang, J., Bengoufa, D., Lavie, F., Zhou, T., & Kimberly, R. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.62.2.168 · Cited by 554
Self-citationStohl, W., Metyas, S., Tan, S., Cheema, G. S., Oamar, B., Xu, D., Roschke, V., Wu, Y., Baker, K. P., & Hilbert, D. M. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11354 · Cited by 503
Self-citationKayagaki, N., Yan, M., Seshasayee, D., Wang, H., Lee, W., French, D. M., Grewal, I. S., Cochran, A. G., Gordon, N. C., Yin, J., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00425-9 · Cited by 477
Metadata
- Authors
- Zhang, J., Roschke, V., Baker, K. P., Wang, Z., Alarcón, G. S., Fessler, B. J., Bastian, H., Kimberly, R. P., & Zhou, T.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-01-01
- Volume
- 166
- Issue
- 1
- Pages
- 6-10
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1920115643
- Cited by
- 734
- References
- 0
- FWCI
- 24.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Zhang, J., Roschke, V., Baker, K. P., Wang, Z., Alarcón, G. S., Fessler, B. J., Bastian, H., Kimberly, R. P., & Zhou, T. (2001). Cutting Edge: A Role for B Lymphocyte Stimulator in Systemic Lupus Erythematosus. The Journal of Immunology. https://doi.org/10.4049/jimmunol.166.1.6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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