New IL-17 Family Members Promote Th1 or Th2 Responses in the Lung: In Vivo Function of the Novel Cytokine IL-25

Hurst, Stephen D; Muchamuel, Tony; Gorman, Daniel M; Gilbert, Jonathan M; Clifford, Theresa; Kwan, Sylvia; Menon, Satish; Seymour, Brian; Jackson, Craig; Kung, Ted T; Brieland, Joan K; Zurawski, Sandra M; Chapman, Richard W; Zurawski, Gerard; Coffman, Robert L

doi:10.4049/jimmunol.169.1.443

New IL-17 Family Members Promote Th1 or Th2 Responses in the Lung: In Vivo Function of the Novel Cytokine IL-25

We have biologically characterized two new members of the IL-17 cytokine family: IL-17F and IL-25. In contrast to conventional in vitro screening approaches, we have characterized the activity of these new molecules by direct in vivo analysis and have compared their function to that of other IL-1…