Human Intestinal Epithelial Cells Are Broadly Unresponsive to Toll-Like Receptor 2-Dependent Bacterial Ligands: Implications for Host-Microbial Interactions in the Gut
Melmed, Gil, Thomas, Lisa S, Lee, Nahee, Tesfay, Samuel Y, Lukasek, Katie, Michelsen, Kathrin S, Zhou, Yuehua, Hu, Bing, Arditi, Moshe, Abreu, Maria T·2003·The Journal of Immunology
Cited by (431)
Items 301–400 of 431
- Gut microbiota-dependent adaptor molecule recruits DNA methyltransferase to the TLR4 gene in colonic epithelial cells to suppress inflammatory reactionsHikari Narabayashi, Chiharu Koma, Kazuaki Nakata, Mion Ikegami, Yusuke Nakanishi, Jun Ogihara, Masato Tsuda, Akira Hosono, Shigemasa Hanazawa, Kyôko Takahashi · 2022 · Frontiers in Molecular Biosciences
- Modulation of chemokine gene expression by Shiga-toxin producing Escherichia coli belonging to various origins and serotypesAlain P. Gobert, Alix T. Coste, Carlos A. Guzmán, Marjolaine Vareille-Delarbre, Thomas Hindré, Thibaut de Sablet, J P Girardeau, Christine Martin · 2007 · Microbes and Infection
- The Effect of Lactobacillus acidophilus PTCC 1643 on Cultured Intestinal Epithelial Cells Infected with Salmonella enterica serovar EnteritidisMona Moshiri, Mohammad Mehdi Soltan Dallal, Farhad Rezaei, Masoumeh Douraghi, Laleh Sharifi, Zahra Noroozbabaei, Mehrdad Gholami, Abbas Mirshafiey · 2017 · Osong Public Health and Research Perspectives
- The Role of Innate Immunity in the Host Defense Against Intestinal Bacterial PathogensJohn P. Sotolongo, Jose R. Ruiz, Masayuki Fukata · 2011 · Current Infectious Disease Reports
- New insights into the pathogenesis of inflammatory bowel diseaseGil Melmed, Maria Teresa Abreu · 2004 · Current Gastroenterology Reports
- Whole-genome microarray analysis and functional characterization reveal distinct gene expression profiles and patterns in two mouse models of ileal inflammationLeela Rani Avula, Dries Knapen, Roeland Buckinx, Lucia Vergauwen, Dirk Adriaensen, Luc Van Nassauw, Jean‐Pierre Timmermans · 2012 · BMC Genomics
- Establishment of Intestinal Epithelial Cell Lines from Adult Mouse Small and Large Intestinal CryptsT. Iwamoto, Kiyoshi YAMADA, Makoto Shimizu, Mamoru Totsuka · 2011 · Bioscience Biotechnology and Biochemistry
- Influence of natural gut flora on immune responseAnna Strzępa, Marian Szczepanik · 2013 · Postępy Higieny i Medycyny Doświadczalnej
- Virus like particles of GII.4 norovirus bind Toll Like Receptors 2 and 5Eleonora Ponterio, Sabrina Mariotti, Claudio Tabolacci, Franco Maria Ruggeri, Roberto Nisini · 2019 · Immunology Letters
- Role of Toll-like receptors in microbiota-associated gastrointestinal cancer metastasisHao Ding, Qi Lu, Weiping Li · 2013 · Journal of Cancer Research and Therapeutics
- Post-Transcriptional Regulation of Toll-Interacting Protein in the Intestinal EpitheliumYutaka Sugi, Kyôko Takahashi, Kenta Kurihara, Kazuaki Nakata, Hikari Narabayashi, Yuji Hamamoto, Makoto Suzuki, Masato Tsuda, Shigemasa Hanazawa, Akira Hosono et al. · 2016 · PLoS ONE
- Immunophysiology of epithelial cells and pattern-recognition receptorsК. А. Лебедев, I. D. Ponyakina · 2006 · Human Physiology
- Correction: Functional Metagenomics: A High Throughput Screening Method to Decipher Microbiota-Driven NF-κB Modulation in the Human GutOmar Lakhdari, Antonietta Cultrone, Julien Tap, Karine Gloux, Françoise Bernard, Stanislav Dusko Ehrlich, Fabrice Lefèvre, Joel M. Dore, Hervé M. Blottière · 2010 · PLoS ONE
- Characterization and expression analysis of Toll-interacting protein in common carp, Cyprinus carpio L., responding to bacterial and viral challengeShijuan Shan, Lei Wang, Fumiao Zhang, Yaoyao Zhu, Liguo An, Guiwen Yang · 2016 · SpringerPlus
- TLR4 Participates in the Inflammatory Response Induced by the AAF/II Fimbriae From Enteroaggregative Escherichia coli on Intestinal Epithelial CellsAlejandra Alvestegui, Mauricio Olivares-Morales, Ernesto Muñoz, Rachel Smith, James P. Nataro, Fernando Ruı́z-Pérez, Mauricio J. Farfán · 2019 · Frontiers in Cellular and Infection Microbiology
- Probiotics and prevention of neonatal necrotizing enterocolitisBrandy L. Frost, Michael S. Caplan · 2011 · Current Opinion in Pediatrics
- Intestinal microecology dysbiosis in inflammatory bowel disease: Pathogenesis and therapeutic strategiesYue Yin, Weibo Feng, Xilang Chen, Jie Chen, Guodong Wang, Limin Xia, Kaichun Wu · 2024 · The Innovation Medicine
- New Model for Studying the Migration of Immune Cells into Intestinal Epithelial Cell MonolayersAkira S. Mori, Hideo Satsu, Makoto Shimizu · 2003 · Cytotechnology
- Gut bacteria characteristic of the infant microbiota down-regulate inflammatory transcriptional responses in HT-29 cellsSiva Gowri Pathmanathan, Blair Lawley, Michelle A. McConnell, Margaret A. Baird, Gerald W. Tannock · 2019 · Anaerobe
- Immunomodulation of J774A.1 Murine Macrophages by Lactiplantibacillus plantarum Strains Isolated From the Human Gastrointestinal Tract and Fermented FoodsNatalia García-González, María Ángeles Núñez‐Sánchez, Miguel Villoria Recio, Natalia Battista, Cormac G. M. Gahan, Aldo Corsetti · 2021 · Frontiers in Microbiology
- Toll-like receptors: a novel target for therapeutic intervention in intestinal and hepatic ischemia–reperfusion injury?Ioanna Vasileiou, Georgia G Kostopanagiotou, Αthanasios Katsargyris, Chris N. Klonaris, Despina N Perrea, Stamatios E Theocharis · 2010 · Expert Opinion on Therapeutic Targets
- Novel Treatments for NEC: Keeping IBD in MindSanjiv Harpavat, Mohan Pammi, Mark A. Gilger · 2012 · Current Gastroenterology Reports
- Infection of human intestinal epithelial cells by invasive bacteria activates NF-κB and increases ICAM-1 expression through NOD1Woon Geon Shin, Bum-Joon Park, Sung Joong Lee, Jae Gyu Kim · 2017 · The Korean Journal of Internal Medicine
- How not to get bugged by bugs: mechanisms of cellular tolerance to microorganismsBobby J. Cherayil · 2003 · Current Opinion in Gastroenterology
- Collateral damage: Sepsis-induced gut injury*M.A. Haseeb, Martin J. Salwen · 2005 · Critical Care Medicine
- What are toll-like receptors and what role may they have in IBD?Masayuki Fukata, Maria Teresa Abreu · 2008 · Inflammatory Bowel Diseases
- Differential response to bacteria, and TOLLIP expression, in the human respiratory tractOlga Lucia Moncayo-Nieto, Thomas S. Wilkinson, Mairi Brittan, Brian J. McHugh, Richard O. Jones, Andrew Conway Morris, W. S. G. Walker, Donald J. Davidson, A. John Simpson · 2014 · BMJ Open Respiratory Research
- Tools for probing host-bacteria interactions in the gut microenvironment: From molecular to cellular levelsKimberly A. Wodzanowski, Samantha E. Cassel, Catherine Leimkuhler Grimes, April M. Kloxin · 2020 · Bioorganic & Medicinal Chemistry Letters
- Microbial exposure early in life regulates airway inflammation in mice after infection with Streptococcus pneumoniae with enhancement of local resistanceYasuki Yasuda, Yoko Matsumura, Kazuki Kasahara, Noriko Ouji, Shigeki Sugiura, Keiichi Mikasa, Eiji Kita · 2009 · American Journal of Physiology-Lung Cellular and Molecular Physiology
- Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talkR. Mukherjee, Melanie van de Kaa, Johan Garssen, Roland J. Pieters, Aletta D. Kraneveld, Linette E. M. Willemsen · 2019 · Food & Function
- Pathogenesis of Inflammatory Bowel DiseaseGiovanni Di Nardo, Salvatore Cucchiara · 2009 · Pediatric and adolescent medicine
- Practical Techniques for Detection of Toll-Like Receptor-4 in the Human IntestineRyan C. Ungaro, Maria Teresa Abreu, Masayuki Fukata · 2009 · Methods in molecular biology
- Eosinophil-derived interferon-lambda contributes to initiation of allergen-related inflammation in the intestineShaoheng He, Chunhua Song, Zhigang Liu, Huiyun Zhang, Wenjing Ma, Linfu Zhou, Tahrin Mahmood, Ping–Chang Yang · 2012 · Cytokine
- The airway epithelium in health and disease: "calm on the surface, paddling furiously underneath"Rosalind Louise Smyth · 2009 · Thorax
- Bacterial Colonization in the Developing Gastrointestinal Tract: Role in the Pathogenesis of Intestinal DiseasesHai Ning Shi, W. Allan Walker · 2004 · Bioscience and Microflora
- Correction: Functional Metagenomics: A High Throughput Screening Method to Decipher Microbiota-Driven NF-κB Modulation in the Human GutOmar Lakhdari, Antonietta Cultrone, Julien Tap, Karine Gloux, Françoise Bernard, Stanislav Dusko Ehrlich, Fabrice Lefèvre, Joel M. Dore, Hervé M. Blottière · 2010 · PLoS ONE
- Innate ImmunityLars Eckmann · 2006 · Elsevier eBooks
- Stage-specific expression of Toll-like receptors in the seminiferous epithelium of mouse testisGöksel Doğan, Mustafa Sandıkçı, Levent Karagenç · 2024 · Histochemistry and Cell Biology
- Bovine lactoferrin increases the poly(I:C)-induced antiviral response in vitroMichiyo Kobayashi‐Sakamoto, T Maeda, Miyuki Kimura, Junko Yusa, Hiroshi Ito, Hideki Tani, Yukio Kato, Kimiharu Hirose · 2022 · Biochemistry and Cell Biology
- Mucin Depleted Foci, Colonic Preneoplastic Lesions Lacking Muc2, Show Up-Regulation of Tlr2 but Not Bacterial InfiltrationAngelo Pietro Femia, Alexander V. Swidsinski, Piero Dolara, Maddalena Salvadori, Amedeo Amedei, Giovanna Caderni · 2012 · PLoS ONE
- Stimulation of colorectal biopsies from miniature dachshunds with inflammatory colorectal polyps with toll-like receptor ligands: A pilot studyNozomu Yokoyama, Hiroshi Ohta, Yumiko Kagawa, Noriyuki Nagata, Khoirun Nisa, Tomoya Morita, Tatsuyuki Osuga, Noboru Sasaki, Keitaro Morishita, Kensuke Nakamura et al. · 2017 · Veterinary Immunology and Immunopathology
- Immunomodulatory Functions of the Gastrointestinal TractMenizibeya Osain Welcome · 2018 · Springer eBooks
- The Multifaceted Effects of Gut Microbiota on the Immune System of the Intestinal MucosaTakehiro Hirano, Hiroshi Nakase · 2021 · Immuno
- Immunophysiology and nutrition of the gut.E. E. Mannick, Z. Zhang, John Nicholas Udall, W. Allan Walker, John B. Watkins, Cian Duggan · 2008
- Role of Epithelial Cells in Mucosal Antigen PresentationLloyd Mayer, Richard S. Blumberg · 2005 · Elsevier eBooks
- Lysozyme promotes the release of toll-like receptor-2 stimulants from Gram-positive but not Gram-negative intestinal bacteriaClett Erridge · 2010 · Gut Microbes
- Effect of oral administration of Limosilactobacillus reuteri on intestinal barrier function and mucosal immunity of suckling pigletsQi Wang, Jing Wang, Renli Qi, Xiaoyu Qiu, Qian Sun, Jinxiu Huang, Rui‐Sheng Wang · 2022 · Italian Journal of Animal Science
- Alternative TLRs are stimulated by bacterial ligand to induce TLR2-unresponsive colon cell responseSubhadeep Mukherjee, Ratna Biswas, Tapas Biswas · 2013 · Cellular Signalling
- Effect of soybean oligosaccharides on immunity and TLR2—NF-κB signal pathway response for weanling pigsZheng Ruan, Yang LingYuan, Xiaoli Zhou, Changqing Zhu, Xugang Shu, Xin Wu, Hua Li, Ling Wang, Bo Jiang · 2012 · Journal of Food Agriculture & Environment
- New immunology—immunology of pattern recognition receptorsК. А. Лебедев, I. D. Ponyakina · 2006 · Biology Bulletin
- Mucosal Immunity: Lessons from the Lower Respiratory and Small Intestinal EpitheliaKayle Dickson, Andrew W. Stadnyk, Juan Zhou, Christine Lehmann · 2025 · Biomedicines
- Host Defense Peptides as Innate Immunomodulators in the Pathogenesis of ColitisRavi Holani, Maia Solange Marin, John Patrick Kastelic, Eduardo Ruben Cobo · 2018 · Elsevier eBooks
- Gut Bacteria Provide Genetic and Molecular Reporter Systems to Identify Specific DiseasesLeon M. T. Dicks · 2024 · International Journal of Molecular Sciences
- Mucosal Bacterial Recognition and Signaling Systems in the IntestineMasayuki Fukata, Maria Teresa Abreu · 2012 · Elsevier eBooks
- Mucosal Homeostasis of the Oral MucosaJean‐Pierre Allam, Natalija Novak · 2018 · Springer eBooks
- PROBIOTIC-HUMAN IMMUNE SYSTEM INTERACTIONSDicle Dilara Akpınar, Burcu Kaplan Türköz · 2019 · Food and Health
- Bacterial cell envelope components of gut commensals: effects in host-microbe interactionThais Vilela Rodrigues, Luís Cláudio Lima de Jesus, Philippe Langella, Siomar de Castro Soares, Gwénaël Jan, Vasco Ariston de Carvalho Azevedo, Jean‐Marc Chatel · 2026 · Annals of Medicine
- Innate and Adaptive Immune Responses duringListeria monocytogenesInfectionSarah E. F. D’Orazio · 2019 · ASM Press eBooks
- The analysis of the impacting factors of probiotics on immune responsesZhipeng Li · 2012 · African Journal of Microbiology Research
- Characterization of the TRAF3IP1 gene in Yesso scallop (Patinopecten yessoensis) and its expression in response to bacterial challengeJie Cheng, Jing Wang, Shuyue Wang, Ruojiao Li, Xianhui Ning, Qiang Xing, Xiaoli Ma, Lingling Zhang, Shi Wang, Xiaoli Hu et al. · 2016 · Genes & Genetic Systems
- Antimicrobial Peptides: Effectors of Innate ImmunityMICHAEL A. ZASLOFF · 2014 · ASM Press eBooks
- MICROBIAL CONTRIBUTIONS TO GUT DEVELOPMENT IN THE NEONATAL PIGBenjamin P. Willing · 2007 · University Library - University of Saskatchewan (University of Saskatchewan)
- Studies on the impact of probiotic bacteria on enteric microbial diversity and immune responseXiyang Wu · 2006 · Research Online (University of Wollongong)
- The Gastrointestinal Immune SystemChang H. Kim · 2014 · Elsevier eBooks
- Elucidation of cellular signaling mechanism involved in Vibrio cholerae chitin-binding protein GbpA mediated IL-8 secretion in the intestinal cellsAvishek Ghosh · 2024 · Infectious Medicine
- Morphological and immunological characterization of primary cultured chicken caecal epithelial cellsThomas Willer, Annette Kaiser, Adrian P L Smith, Silke Rautenschlein · 2024 · European Journal of Microbiology and Immunology
- Peptidoglycan from Staphylococcus aureus induces the overexpression of TRLs 1-8 mRNA in corneal fibroblasts, but its lipoteichoic acid and muramyl dipeptide only induced the overexpression of TLR5 or TRL9Sandra Rodríguez–Martínez, Norma Angélica Sánchez-Zauco, Ivonne González-Ramírez, Juan C. Cancino‐Díaz, Mario Eugenio Cancino-Diaz · 2011 · Brazilian Journal of Microbiology
- Antibacterial Activity of the p53 Tumor Suppressor Protein—How Strong Is the Evidence?Agnieszka Gdowicz‐Kłosok, Małgorzata Krześniak, Barbara Łasut-Szyszka, Dorota Butkiewicz, Marek Rusin · 2025 · International Journal of Molecular Sciences
- Influence of Toll-like receptor 2 and interleukin 10 on the intestinal epithelial barrier and their roles in inflammatory bowel diseaseJosep Mañé Almero · 2011 · Inmunología
- Innate Immunity: A Potent Target for Management of Inflammatory Bowel DiseaseMasayuki Fukata · 2012 · InTech eBooks
- Microparticles and the Hygiene HypothesisPablo I. Martín, Pablo Alejandro Sánchez, ENRIQUE REWALD · 2009 · Annals of the New York Academy of Sciences
- Innate Immunity and Microbes: Conversations with the Gut Leading to Intestinal Tissue Repair and FibrosisDeanna Lynn Gibson, Marinieve Montero, Natasha R. Ryz, Bruce Andrew Vallance · 2009 · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
- REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY Microbes in Gastrointestinal Health and DiseaseAndrew Scott Neish · 2009
- The Gastrointestinal Immune System*Chang H. Kim, Fergus Shanahan · 2010 · Elsevier eBooks
- Molecular and physiological studies on the functionality of probiotic lactobacilliVizoso Pinto, María Guadalupe · 2007
- The Influence of the Microbiota on the Etiology of Colorectal CancerMelissa C. Kordahi, R. William DePaolo · 2018 · Springer eBooks
- Canine primary jejunal and colonic epithelial cells predominantly express TLR5 and TLR9 but do not change TLR expression pattern after stimulation with certain Toll-like receptor ligandsWencke Reineking, Johannes Junginger, Reinhard H. Mischke, Marion Hewicker‐Trautwein · 2018 · Veterinary Immunology and Immunopathology
- Toll-like receptors and inflammatory bowel diseaseMasayuki Fukata, Maria Teresa Abreu · 2006 · Birkhäuser Basel eBooks
- A tissue-scale strategy for sensing threats in barrier organsDiep H. Nguyen, Jiakun Tian, Sean-Luc Shanahan, Connie Wang, Tyler Jacks, Xiao Wang, Pulin Li · 2026 · Cell Systems
- Study of the modulation of innate immune responses in intestinal epithelial cells by Toxoplasma gondii and its correlation with parasite virulenceVijay Morampudi, Michel Y. Braun · 2010
- Toll-Like Receptors as Biomarkers of Gastric Carcinogenesis: Implications for Diagnosis, Prognosis and TreatmentPedro Pimentel‐Nunes, João–Bruno Soares, Mário Jorge Dinis-Ribeiro · 2013 · Journal of Cancer Therapy
- Epigenetic Modifications in Gram-Negative Bacteria and the Induction of Patho-Epigenetic Modifications in Host TissueAndreas Erich Zautner, Hagen Frickmann · 2013 · GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen)
- Mukosale Homöostase und orale ToleranzJean‐Pierre Allam, Natalija Novak · 2013 · Allergo Journal
- Immunologic Response in the HostKaren L. Madsen, H. Park · 2017 · Elsevier eBooks
- Innate Immunity and its Implications on Pathogenesis of Inflammatory Bowel DiseaseMaria Teresa Abreu, Masayuki Fukata, Keith J. Breglio · 2010 · Wiley eBooks
- Linkage between innate and acquired immunities at the mucosaOsamu Igarashi, Tomonori Nochi, Kazutaka Terahara, Hiroshi Kiyono · 2005 · International Congress Series
- The Immunological Role of Enterocytes and Probiotics in Necrotizing EnterocolitisKristian Leonard Jack Thomson · 2014 · Otago University Research Archive (University of Otago)
- Defence capabilities of human intestinal epithelial cellsAnna Fahlgren · 2003 · DiVA at Umeå University (Umeå University)
- The impact of commensals predominant in the infant gut on signal cascades in epithelial cellsSiva Gowri Pathmanathan · 2015 · Otago University Research Archive (University of Otago)
- The expression of Toll-like receptors-2 and-4 by human crypt intestinal epithelial cells, intestinal myofibroblasts and putative intestinal stem cells in inflammatory bowel diseaseMatthew Brown · 2012 · Nottingham ePrints (University of Nottingham)
- Microbial Sensing in the Intestine by Pattern Recognition ReceptorsRobin G. Lorenz, Charles O. Elson · 2006
- Microbial regulation of allergic inflammationDavid A. Hill · 2011 · Scholarly Commons (University of Pennsylvania)
- Mucosal Immune Regulation in Early Infancy: Monitoring and InterventionJeroen Hol · 2004 · RePub (Erasmus University Rotterdam)
- Expression and Role of Anaphylatoxin Receptors on Human Colonic Epithelial CellsQi Cao · 2013 · DalSpace (Dalhousie University)
- Role of Pattern Recognition Receptors in Modulating Intestinal Immune Responses and Potential Therapeutic Implications for Inflammatory Bowel DiseasesCario Elke, Daniel K. Podolsky · 2007 · Wiley eBooks
- Antimicrobial peptides and pathogenic Neissera : Experimental studies in mouse, man and ratPeter Bergman · 2005 · Figshare
- Campylobacter jejuni/coli - Host Intestinal Epithelial Cell InteractionJie Zheng · 2006 · University Libraries (University of Maryland)
- Differential expression of duck Toll-like receptor 7 (dTLR7) in various organs of indigenous ducksK. Gautham, N. Ramamurthy, R. Richard Churchil, T. R. Kannaki · 2013 · Veterinary World
- Physiological role of the functions of pattern recognition receptors in immunologyК. А. Лебедев · 2007 · Human Physiology
- Attenuation of Oxidative Stress, Inflammation and Colorectal Oncogenesis by Food Constituents: Ischaemia/Reperfusion Injury and Induced Colitis in RodentsÅsa Håkansson · 2010 · Lund University Publications (Lund University)