The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice
Open accessAbstract
Interleukin-17 is a T cell-derived proinflammatory cytokine. This cytokine is suspected to be involved in the development of rheumatoid arthritis (RA) because this cytokine expression is augmented in synovial tissues of RA patients. The pathogenic roles of IL-17 in the development of RA, however, still remain to be elucidated. In this study, effects of IL-17 deficiency on collagen-induced arthritis (CIA) model were examined using IL-17-deficient mice (IL-17−/− mice). We found that CIA was markedly suppressed in IL-17−/− mice. IL-17 was responsible for the priming of collagen-specific T cells and collagen-specific IgG2a production. Thus, these observations suggest that IL-17 plays a crucial role in the development of CIA by activating autoantigen-specific cellular and humoral immune responses.
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Citations
Cites
Microbial lipopeptides induce the production of IL-17 in Th cells
Infante-Duarte, C., Horton, H. F., Byrne, M. C., & Kamradt, T. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6107 · Cited by 586 · cited 2×
“In contrast, inflammatory cytokines, TNF- and GM-CSF, which are also produced by CD4 T cells (9), are suggested to have an important role in the RA pathogenesis.”
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Cited by
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
Liang, S. C., Tan, X.-Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., & Fouser, L. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061308 · Cited by 2,330
Metadata
- Authors
- Nakae, S., Nambu, A., Sudo, K., & Iwakura, Y.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-12-01
- Volume
- 171
- Issue
- 11
- Pages
- 6173-6177
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2136357996
- Cited by
- 1,273
- References
- 1
- FWCI
- 11.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice. https://app.cochat.ai/papers/10.4049/jimmunol.171.11.6173
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- Nakae, S., Nambu, A., Sudo, K., & Iwakura, Y. (2003). Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice. The Journal of Immunology. https://doi.org/10.4049/jimmunol.171.11.6173
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