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Membranous Cells in Nasal-Associated Lymphoid Tissue: A Portal of Entry for the Respiratory Mucosal Pathogen Group A Streptococcus
Abstract
Human tonsils are suspected to be an antibiotic-impervious human reservoir for group A streptococcus. An intranasal infection model in mice and a bioluminescent-tagged strain were used to investigate this possibility. Viable streptococci were predominantly found both intra- and extracellularly in nasal-associated lymphoid tissue (NALT), a human tonsil homologue. Ulex europaeus-1, a membranous (M) cell-specific lectin, identified cells harboring streptococci at the epithelial surface of NALT and blocked bacterial colonization of this tissue. These results suggest that M cells in NALT transport this Gram-positive pathogen across the epithelial layers in a manner similar to those in Peyer’s patches, which permit enteric pathogens to invade deeper tissues from the gastrointestinal tract.
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Citations
Cited by
NALT- versus PEYER'S-patch-mediated mucosal immunity
Kiyono, H., & Fukuyama, S. (2004) · Nature Reviews Immunology · doi:10.1038/nri1439 · Cited by 745
Persistent bacterial infections: the interface of the pathogen and the host immune system
Monack, D. M., Mueller, A., & Falkow, S. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro955 · Cited by 572
Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties
Brandtzaeg, P., & Johansen, F. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00283.x · Cited by 447
Dileepan, T., Smith, E. D., Knowland, D., Hsu, M., Platt, M., Bittner-Eddy, P., Cohen, B., Southern, P., Latimer, E., Harley, E., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80792 · Cited by 128
Self-citationKim, D.-Y., Sato, A., Fukuyama, S., Sagara, H., Nagatake, T., Kong, I. G., Goda, K., Nochi, T., Kunisawa, J., Sato, S., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.0903794 · Cited by 115
Metadata
- Authors
- Park, H.-S., Francis, K. P., Yu, J., & Cleary, P. P.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-09-01
- Volume
- 171
- Issue
- 5
- Pages
- 2532-2537
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2124333113
- Cited by
- 161
- References
- 0
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Park, H.-S., Francis, K. P., Yu, J., & Cleary, P. P. (2003). Membranous Cells in Nasal-Associated Lymphoid Tissue: A Portal of Entry for the Respiratory Mucosal Pathogen Group A Streptococcus. The Journal of Immunology. https://doi.org/10.4049/jimmunol.171.5.2532
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
