The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
CCR7 Directs the Migration of Thymocytes into the Thymic Medulla
Abstract
Developing thymocytes migrate from the cortex to the medulla of the thymus as a consequence of positive selection. This migration is likely to be essential for tolerance because it allows the developing cells to move into an environment that is optimal for negative selection. Guidance mechanisms that draw positively selected thymocytes into the medulla have not been clarified, but several studies have implicated chemokines in the process. CCR7, the receptor for the medullary chemokines CCL19 and CCL21, is induced on thymocytes during their positive selection. In this study we show that premature expression of CCR7 repositions CD4+CD8+ double-positive cells into the medulla of transgenic mice. This repositioning of the thymocytes is accompanied by impairment of their development. The data show the involvement of CCR7 in medullary migration and emphasize the importance of proper thymocyte positioning for efficient T cell development.
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Citations
Cites
The Biology of Chemokines and their Receptors
Rossi, D., & Zlotnik, A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.217 · Cited by 2,410
Cited by
Journey through the thymus: stromal guides for T-cell development and selection
Takahama, Y. (2006) · Nature Reviews Immunology · doi:10.1038/nri1781 · Cited by 728
Haynes, N. M., Allen, C. D. C., Lesley, R., Ansel, K. M., Killeen, N., & Cyster, J. G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5099 · Cited by 694
Self-citationZoned Out: Functional Mapping of Stromal Signaling Microenvironments in the Thymus
Petrie, H. T., & Zúñiga-Pflücker, J. C. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115715 · Cited by 454
Hikosaka, Y., Nitta, T., Ohigashi, I., Yano, K., Ishimaru, N., Hayashi, Y., Matsumoto, M., Matsuo, K., Penninger, J. M., Takayanagi, H., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.06.018 · Cited by 433
Self-representation in the thymus: an extended view
Kyewski, B., & Derbinski, J. (2004) · Nature Reviews Immunology · doi:10.1038/nri1436 · Cited by 342
Metadata
- Authors
- Kwan, J., & Killeen, N.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-04-01
- Volume
- 172
- Issue
- 7
- Pages
- 3999-4007
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1885758189
- Cited by
- 187
- References
- 1
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kwan, J., & Killeen, N. (2004). CCR7 Directs the Migration of Thymocytes into the Thymic Medulla. The Journal of Immunology. https://doi.org/10.4049/jimmunol.172.7.3999
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
