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Analysis of the 5q31-q33 Locus Shows an Association between IL13-1055C/T IL-13-591A/G Polymorphisms and Schistosoma haematobium Infections
Abstract
Millions of humans are exposed to schistosome infections, which cause severe kidney and liver disease and 280,000 deaths annually. Th2-mediated immunity is critical to human defenses against this pathogen and susceptibility to infection is controlled by a major genetic locus that includes IL4, IL5, and IL13 genes. These observations led us to evaluate whether certain polymorphisms in IL4, IL5, or IL13 determine schistosome infection. The study was performed in two Dogon villages where Schistosoma haematobium is endemic. Schistosome infections were evaluated by counting eggs and measuring worm Ags in urine. Genetic polymorphisms were determined by restriction enzyme analysis or by primer extension and denaturing high-performance liquid chromatography analysis. Associations were tested using family-based association tests and logistical regression analysis. The alleles IL13-1055C (p = 0.05) and IL13-591A (p = 0.01) are shown, by family-based association test, to be preferentially transmitted to children with the 10% highest infections. A logistic regression analysis that included IL13-1055 G/G, G/T and T/T genotypes, age, gender, and village of residency, applied to the whole study population, showed that subjects bearing the IL13-1055T/T genotype were on average much less infected than individuals with other genotypes. Previous studies on asthma indicated that the IL13-1055T allele increased gene transcription, which is in agreement with the fact that this cytokine enhances resistance to infection by schistosome in humans.
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“Resistance to Schistosoma haematobium was associated with the IL13-1055T/T genotype, 62 which has also been implicated in asthma exacerbations.63”
From Global issues in allergy and immunology: Parasitic infections and allergy (2017) · cites this paper as [62]
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Cited by
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Filbey, K. J., Grainger, J. R., Smith, K. A., Boon, L., van Rooijen, N., Harcus, Y., Jenkins, S., Hewitson, J. P., & Maizels, R. M. (2014) · Immunology & Cell Biology · doi:10.1038/icb.2013.109 · Cited by 130
Global issues in allergy and immunology: Parasitic infections and allergy
Cruz, A. A., Cooper, P. J., Figueiredo, C. A., Alcantara-Neves, N. M., Rodrigues, L. C., & Barreto, M. L. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.09.005 · Cited by 82
Metadata
- Authors
- Kouriba, B., Chevillard, C., Bream, J. H., Argiro, L., Dessein, H., Arnaud, V., Sangare, L., Dabo, A., Beavogui, A. H., Arama, C., Traoré, H. A., Doumbo, O., & Dessein, A.
- Affiliations
- Department of Epidemiology and Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto-Stomatology , Bamako ,
- Laboratory of Parasitology-Mycology, Faculty of Medicine, Institut National de la Santé et de la Recherche Médicale, Unité 399 , Marseille ,
- Disease Prevention and Control Program, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University , Baltimore, MD 21205
- Service of Internal Medicine, National Hospital of Point “G” , Bamako ,
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-05
- Volume
- 174
- Issue
- 10
- Pages
- 6274-6281
- ISSN
- 0022-1767
- 1550-6606
- Cited by
- 71
- References
- 0
- Language
- en
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