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Cited by 51Cytokine Signaling Pathways and InteractionsRespiratory viral infections researchNeonatal Respiratory Health Research

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Stat3 Is Required for Cytoprotection of the Respiratory Epithelium during Adenoviral Infection

Matsuzaki, Yohei, Xu, Yan, Ikegami, Machiko, Besnard, Valérie, Park, Kwon-Sik, Hull, William M, Wert, Susan E, Whitsett, Jeffrey A·2006·The Journal of Immunology
DOI 10.4049/jimmunol.177.1.527
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Abstract

The role of Stat3 in the maintenance of pulmonary homeostasis following adenoviral-mediated lung injury was assessed in vivo. Stat3 was selectively deleted from bronchiolar and alveolar epithelial cells in Stat3(DeltaDelta) mice. Although lung histology and function were unaltered by deletion of Stat3 in vivo, Stat3(DeltaDelta) mice were highly susceptible to lung injury caused by intratracheal administration of AV1-GFP, an early (E) region 1- and E3-deleted, nonproliferative adenovirus. Severe airspace enlargement, loss of alveolar septae, and sloughing of the bronchiolar epithelium were observed in Stat3(DeltaDelta) mice as early as 1 day after exposure to the virus. Although surfactant protein A, B, and C content and surfactant protein-B mRNA expression in Stat3(DeltaDelta) mice were similar, TUNEL staining and caspase-3 were increased in alveolar type II epithelial cells of Stat3(DeltaDelta) mice after exposure to virus. RNA microarray analysis of type II epithelial cells isolated from Stat3(DeltaDelta) mice demonstrated significant changes in expression of numerous genes, including those genes regulating apoptosis, supporting the concept that the susceptibility of Stat3-deficient mice to adenovirus was related to the role of Stat3 in the regulation of cell survival. AV1-Bcl-x(L), an E1- and E3-deleted, nonproliferative adenovirus expressing the antiapoptotic protein Bcl-x(L), protected Stat3(DeltaDelta) mice from adenoviral-induced lung injury. Adenoviral infection of the lungs of Stat3-deficient mice was associated with severe injury of the alveolar and bronchiolar epithelium. Thus, Stat3 plays a critical cytoprotective role that is required for epithelial cell survival and maintenance of alveolar structures during the early phases of pulmonary adenoviral infection.

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Crossref · 10.4049/jimmunol.177.1.527

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  • Glucocorticoids are crucial during fetal development for the functional maturation of the respiratory system.

    “Glucocorticoids are crucial during fetal development for the functional maturation of the respiratory system [90,91,92] and are currently utilized as the standard of care for women at high risk for preterm delivery to prevent respiratory distress syndrome [93].”

    From Stress and the HPA Axis: Balancing Homeostasis and Fertility. (2017) · cites this paper as [92]

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Metadata

Authors
Matsuzaki, Y., Xu, Y., Ikegami, M., Besnard, V., Park, K.-S., Hull, W. M., Wert, S. E., & Whitsett, J. A.
Affiliations
  • Cincinnati Children's Hospital Medical Center (US)
  • Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, OH 45229
ORCID
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2006-07-01
Volume
177
Issue
1
Pages
527-537
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.177.1.527
OpenAlex
W1630706121
Cited by
51
References
3
Citations by year
2025: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2018: 5 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 6
FWCI
2.61
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • Hyogo College of Medicine
  • National Heart, Lung, and Blood Institute (HL-38859, HL-61646, P01HL061646)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
Keywords
STAT3, adenovirus infection, lung injury, respiratory epithelium, cytoprotection, epithelial cell survival, apoptosis, alveolar type II cells, Bcl-xL, surfactant proteins, caspase-3
MeSH terms
Adenoviridae Infections, Animals, Cell Line, Humans, Intubation, Intratracheal, Lung, Mice, Transgenic, Pulmonary Alveoli, Up-Regulation, Gene Expression Regulation, Viral, Apoptosis, Mice, Knockout, Cytoprotection, Genetic Predisposition to Disease, Caspases, Respiratory Mucosa, STAT3 Transcription Factor, bcl-X Protein, Mice, Caspase 3

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