The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Macrophages and Myeloid Dendritic Cells, but Not Plasmacytoid Dendritic Cells, Produce IL-10 in Response to MyD88- and TRIF-Dependent TLR Signals, and TLR-Independent Signals
Open accessAbstract
We have previously reported that mouse plasmacytoid dendritic cells (DC) produce high levels of IL-12p70, whereas bone marrow-derived myeloid DC and splenic DC produce substantially lower levels of this cytokine when activated with the TLR-9 ligand CpG. We now show that in response to CpG stimulation, high levels of IL-10 are secreted by macrophages, intermediate levels by myeloid DC, but no detectable IL-10 is secreted by plasmacytoid DC. MyD88-dependent TLR signals (TLR4, 7, 9 ligation), Toll/IL-1 receptor domain-containing adaptor-dependent TLR signals (TLR3, 4 ligation) as well as non-TLR signals (CD40 ligation) induced macrophages and myeloid DC to produce IL-10 in addition to proinflammatory cytokines. IL-12p70 expression in response to CpG was suppressed by endogenous IL-10 in macrophages, in myeloid DC, and to an even greater extent in splenic CD8α− and CD8α+ DC. Although plasmacytoid DC did not produce IL-10 upon stimulation, addition of this cytokine exogenously suppressed their production of IL-12, TNF, and IFN-α, showing trans but not autocrine regulation of these cytokines by IL-10 in plasmacytoid DC.
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Cites
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Self-citationInterleukin-10 and the Interleukin-10 Receptor
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Self-citationA Toll-like receptor recognizes bacterial DNA
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“Although it is well documented that the production of proinflammatory cytokines upon TLR ligation is MyD88 dependent (21, 47, 48), it has been suggested that the production of the suppressive cytokine IL-10 is favored by usage of pathways involving triggering via C-type lectins, such as dectin-1 and DC-SIGN (38, 39),…”
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“Residual IL-10 production in response to poly(I:C) in TRIF KO macrophages may be due to signaling via a TRIF-independent pathway using Mda-5, recently reported as inducing other proinflammatory cytokines (49).”
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Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
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Cited by
The regulation of IL-10 production by immune cells
Saraiva, M., & O'Garra, A. (2010) · Nature Reviews Immunology · doi:10.1038/nri2711 · Cited by 3,164
Self-citationRegulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease
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Interleukin‐10: new perspectives on an old cytokine
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Synovial inflammation in osteoarthritis progression
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The role of the transcription factor CREB in immune function
Wen, A. Y., Sakamoto, K. M., & Miller, L. S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001829 · Cited by 790
Metadata
- Authors
- Boonstra, A., Rajsbaum, R., Holman, M., Marques, R., Asselin-Paturel, C., Pereira, J. P., Bates, E. E. M., Akira, S., Vieira, P., Liu, Y.-J., Trinchieri, G., & O’Garra, A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-12-01
- Volume
- 177
- Issue
- 11
- Pages
- 7551-7558
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2122331051
- Cited by
- 288
- References
- 61
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Macrophages and Myeloid Dendritic Cells, but Not Plasmacytoid Dendritic Cells, Produce IL-10 in Response to MyD88- and TRIF-Dependent TLR Signals, and TLR-Independent Signals. https://app.cochat.ai/papers/10.4049/jimmunol.177.11.7551
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- Boonstra, A., Rajsbaum, R., Holman, M., Marques, R., Asselin-Paturel, C., Pereira, J. P., Bates, E. E. M., Akira, S., Vieira, P., Liu, Y.-J., Trinchieri, G., & O’Garra, A. (2006). Macrophages and Myeloid Dendritic Cells, but Not Plasmacytoid Dendritic Cells, Produce IL-10 in Response to MyD88- and TRIF-Dependent TLR Signals, and TLR-Independent Signals. The Journal of Immunology. https://doi.org/10.4049/jimmunol.177.11.7551
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
