Cited by 249T-cell and B-cell ImmunologyLymphoma Diagnosis and TreatmentDevelopmental Biology and Gene Regulation

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B-1 B Cell Development

Hardy, Richard R·2006·The Journal of Immunology

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Abstract

CD5+ B cells have attracted considerable interest because of their association with self-reactivity, autoimmunity, and leukemia. In mice, CD5+ B cells are readily generated from fetal/neonatal precursors, but inefficiently from precursors in adult. One model proposed to explain this difference is that their production occurs through a distinctive developmental process, termed B-1, that enriches pre-B cells with novel germline VDJs and that requires positive selection of newly formed B cells by self-Ag. In contrast, follicular B cells are generated throughout adult life in a developmental process termed B-2, selecting VDJs that pair well with surrogate L chain, and whose maturation appears relatively independent of antigenic selection. In the present study, I focus on processes that shape the repertoire of mouse CD5+ B cells, describing the differences between B-1 and B-2 development, and propose a model encompassing both in the generation of functional B cell subpopulations.

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Authors: Hardy, R. R.
Affiliations: Fox Chase Cancer Center (US)
Corresponding author: Hardy, Richard R
ORCID: Hardy, Richard R
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2006-09-01
Volume: 177
Issue: 5
Pages: 2749-2754
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.177.5.2749
OpenAlex: W2129375889
Cited by: 249
References: 87
Citations by year: 2026: 4 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 8 · 2021: 8 · 2020: 6 · 2019: 8 · 2018: 12 · 2017: 14 · 2016: 9 · 2015: 10 · 2014: 18 · 2013: 22 · 2012: 17
FWCI: 1.46
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI26782, R01AI040946, AI 40946)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: CD5+ B cells, pre-B cells, V(D)J recombination, positive selection, autoantigens, surrogate light chain, B cell receptor repertoire, autoimmunity, B-cell leukemia
MeSH terms: Animals, B-Lymphocytes, Cell Differentiation, Humans, Lymphocyte Activation, Models, Immunological, CD5 Antigens, Cell Lineage

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