The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
The Relationship between Apoptosis and High-Mobility Group Protein 1 Release from Murine Macrophages Stimulated with Lipopolysaccharide or Polyinosinic-Polycytidylic Acid
Abstract
High-mobility group protein 1 (HMGB1) is a nonhistone nuclear protein whose function depends on cellular location. Inside the cell, HMGB1 modulates a variety of important cellular processes, including transcription, whereas outside the cell, HMGB1 acts as a cytokine that can promote inflammation and mediate sepsis and arthritis in animal models. In in vitro studies, proinflammatory molecules such as LPS, lipoteichoic acid, polyinosinic-polycytidylic acid (poly(I:C)), TNF-α, and type I and II IFNs can induce HMGB1 release from macrophages. Although these agents can activate cells, they can also induce apoptosis under certain circumstances. Therefore, because of evidence that apoptotic as well as necrotic cells can contribute to HMGB1-mediated events in sepsis, we have investigated the relationship between apoptosis and HMGB1 release in macrophages and other cells. In these experiments, using RAW 264.7 cells as a model, LPS and poly(I:C) caused HMGB1 release into the medium whereas CpG ODN failed to induce this response. With both LPS and poly(I:C), the extent of HMGB1 release correlated with the occurrence of apoptosis as measured by caspase 3 activation, lactate dehydrogenase release, and TUNEL staining. Similar results were obtained with primary murine macrophages as well as human Jurkat T cells. For Jurkat cells, poly(I:C) and NO donors induced apoptosis as well as HMGB1 release. Together, these results indicate that HMGB1 release from macrophages is correlated with the occurrence of apoptosis and suggest that these processes reflect common mechanisms and can occur concomitantly.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Although it was initially thought that HMGB1 is released only from the nucleus during primary necrosis, recent data indicate that HMGB1 can be released during secondary necrosis following apoptosis 27,48–50.”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [50]
Citations
Cites
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221
Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., & Fujita, T. (2004) · Nature Immunology · doi:10.1038/ni1087 · Cited by 4,022
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L. V., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,386
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,286
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G. D., Mitchison, T. J., Moskowitz, M. A., & Yuan, J. (2005) · Nature Chemical Biology · doi:10.1038/nchembio711 · Cited by 3,068
Takeda, K., & Akira, S. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2003.10.003 · Cited by 2,528
High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
Lotze, M. T., & Tracey, K. J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1594 · Cited by 2,490
Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
Bonaldi, T., Talamo, F., Scaffidi, P., Ferrera, D., Porto, A., Bachi, A., Rubartelli, A., Agresti, A., & Bianchi, M. E. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg516 · Cited by 1,252
Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T., & Seya, T. (2003) · Nature Immunology · doi:10.1038/ni886 · Cited by 1,217
Nitric oxide-mediated apoptosis in murine peritoneal macrophages
Albina, J. E., Cui, S., Mateo, R. B., & Reichner, J. S. (1993) · Parasitology Today · doi:10.1016/0169-4758(93)90226-6 · Cited by 782
Research works printed but not linked: 43
- 2003, Biochem. Biophys. Res. Commun., 421
- 2003, Nucleic Acids Res., 3236
- 2005, Nat. Rev. Immunol., 331
- 1999, Science, 248
- 2005, J. Leukocyte Biol., 930
- 2003, Arthritis Rheum., 2052
- 2003, EMBO J., 5551
- 2006, J. Immunol., 7889
- 2002, Nature, 191
- 2006, Am. J. Physiol., C1318
- 1987, J. Interferon Res., 511
- 1997, J. Exp. Med., 1831
- 2000, Blood, 3823
- 2004, J. Immunol., 1699
- 2003, J. Immunol., 3890
- 2006, J. Immunol., 3337
- 1993, J. Immunol., 5080
- 1997, Cell Growth Differ., 343
- 1999, J. Infect. Dis., 939
- 1998, Biochem. Biophys. Res. Commun., 790
- 1994, Mol. Cell. Biol., 8376
- 2004, Semin. Immunol., 3
- 1999, Surgery, 389
- 1997, Cancer Res., 3697
- 2001, Oncogene, 4768
- 2002, J. Hepatol., 233
- 2007, J. Leukocyte Biol., 75
- 2003, Am. J. Physiol., C1235
- 2006, J. Immunol., 4894
- 1997, Parasitology, S79
- 1991, J. Virol., 2968
- 1995, Cancer Res., 6012
- 1996, Am. J. Respir. Cell Mol. Biol., 64
- 1998, J. Exp. Med., 2175
- 1999, J. Biol. Chem., 28808
- 2004, Biochem. Biophys. Res. Commun., 60
- 2000, EMBO J., 3630
- 2004, Nat. Immunol., 730
- 2003, Nat. Immunol., 161
- 2003, Science, 640
- 2005, Nat. Chem. Biol., 112
- 2003, J. Exp. Med., 1441
- 2006, J. Exp. Med., 1637
Cited by
Sorted by citations
HMGB1 and RAGE in Inflammation and Cancer
Sims, G. P., Rowe, D. C., Rietdijk, S. T., Herbst, R., & Coyle, A. J. (2010) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132603 · Cited by 1,436
Immunogenic and tolerogenic cell death
Green, D. R., Ferguson, T., Zitvogel, L., & Kroemer, G. (2009) · Nature Reviews Immunology · doi:10.1038/nri2545 · Cited by 1,176
Novel role of PKR in inflammasome activation and HMGB1 release
Lü, B., Nakamura, T., Inouye, K., Li, J., Tang, Y., Lundbäck, P., Valdés‐Ferrer, S. I., Olofsson, P. S., Kalb, T. H., Roth, J., et al. (2012) · Nature · doi:10.1038/nature11290 · Cited by 772
HMGB1: Endogenous Danger Signaling
Klune, J. R., Dhupar, R., Cardinal, J., Billiar, T. R., & Tsung, A. (2008) · Molecular Medicine · doi:10.2119/2008-00034.klune · Cited by 762
Release mechanisms of major DAMPs
Murao, A., Aziz, M., Wang, H., Brenner, M., & Wang, P. (2021) · APOPTOSIS · doi:10.1007/s10495-021-01663-3 · Cited by 590
Metadata
- Authors
- Jiang, W., Bell, C. W., & Pisetsky, D. S.
- Affiliations
- Duke University (US)
- Corresponding author
- Jiang, Weiwen
- ORCID
- Pisetsky, David S
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-05
- Volume
- 178
- Issue
- 10
- Pages
- 6495-6503
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2130822772
- Cited by
- 134
- References
- 45
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 7 · 2014: 5 · 2013: 10 · 2012: 9
- FWCI
- 10.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI44808)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- HMGB1, apoptosis, macrophages, lipopolysaccharide, poly(I:C), CpG oligodeoxynucleotides, caspase-3, necrosis, sepsis, inflammation, Jurkat cells, RAW 264.7 macrophages, nitric oxide donors, HMGB1 release
- MeSH terms
- Animals, Cell Line, Extracellular Space, Female, Humans, Lipopolysaccharides, Macrophage Activation, Mice, Inbred BALB C, Oligodeoxyribonucleotides, Poly I-C, Apoptosis, Macrophages, Peritoneal, Jurkat Cells, Protein Transport, HMGB1 Protein, Toll-Like Receptors, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
