The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Infection with a Helminth Parasite Prevents Experimental Colitis via a Macrophage-Mediated Mechanism
Open accessAbstract
The propensity of a range of parasitic helminths to stimulate a Th2 or regulatory cell-biased response has been proposed to reduce the severity of experimental inflammatory bowel disease. We examined whether infection with Schistosoma mansoni, a trematode parasite, altered the susceptibility of mice to colitis induced by dextran sodium sulfate (DSS). Mice infected with schistosome worms were refractory to DSS-induced colitis. Egg-laying schistosome infections or injection of eggs did not render mice resistant to colitis induced by DSS. Schistosome worm infections prevent colitis by a novel mechanism dependent on macrophages, and not by simple modulation of Th2 responses, or via induction of regulatory CD4+ or CD25+ cells, IL-10, or TGF-β. Infected mice had marked infiltration of macrophages (F4/80+CD11b+CD11c−) into the colon lamina propria and protection from DSS-induced colitis was shown to be macrophage dependent. Resistance from colitis was not due to alternatively activated macrophages. Transfer of colon lamina propria F4/80+ macrophages isolated from worm-infected mice induced significant protection from colitis in recipient mice treated with DSS. Therefore, we propose a new mechanism whereby a parasitic worm suppresses DSS-induced colitis via a novel colon-infiltrating macrophage population.
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Cites
Alternative activation of macrophages
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The Immunology of Mucosal Models of Inflammation
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Experimental models of inflammatory bowel disease
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Immunity, Inflammation, and Allergy in the Gut
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Cited by
Jenkins, S. J., Ruckerl, D., Cook, P. C., Jones, L. H., Finkelman, F. D., van Rooijen, N., MacDonald, A. S., & Allen, J. E. (2011) · Science · doi:10.1126/science.1204351 · Cited by 1,366
Self-citationRegulation of the host immune system by helminth parasites
Maizels, R. M., & McSorley, H. J. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.07.007 · Cited by 529
Helminth infections and host immune regulation
McSorley, H. J., & Maizels, R. M. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.05040-11 · Cited by 499
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The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis
Cummins, E. P., Seeballuck, F., Keely, S. J., Mangan, N. E., Callanan, J. J., Fallon, P. G., & Taylor, C. T. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.10.012 · Cited by 407
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Metadata
- Authors
- Smith, P., Mangan, N. E., Walsh, C. M., Fallon, R. E., McKenzie, A. N. J., van Rooijen, N., & Fallon, P. G.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-04-01
- Volume
- 178
- Issue
- 7
- Pages
- 4557-4566
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1767092522
- Cited by
- 279
- References
- 56
- FWCI
- 12.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Smith, P., Mangan, N. E., Walsh, C. M., Fallon, R. E., McKenzie, A. N. J., van Rooijen, N., & Fallon, P. G. (2007). Infection with a Helminth Parasite Prevents Experimental Colitis via a Macrophage-Mediated Mechanism. The Journal of Immunology. https://doi.org/10.4049/jimmunol.178.7.4557
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