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Cutting Edge: The Dependence of Plasma Cells and Independence of Memory B Cells on BAFF and APRIL
Open accessAbstract
Memory B (BMEM) cells and long-lived bone marrow plasma cells (BM-PCs) persist within local environmental survival niches that afford cellular longevity. However, the factors supporting BMEM cell survival within the secondary lymphoid organs and allowing BM-PC persistence in the bone marrow remain poorly characterized. We report herein that long-lived BMEM cell survival and function are completely independent of BAFF (B cell-activating factor of the TNF family) or APRIL (a proliferation-inducing ligand). Thus, BMEM cells represent the only mature B2 lineage subset whose survival is independent of these ligands. We have previously shown that the TNFR family member receptor BCMA (B cell maturation Ag) is a critical survival receptor for BM-PC survival in vivo. We identify in this study the ligands critical for BM-PC survival and show that either BAFF or APRIL supports the survival of BM-PCs in vivo. These data define the BAFF/APRIL-dependent and -independent components of long-lived humoral immunity.
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Citations
Cited by
The generation of antibody-secreting plasma cells
Nutt, S. L., Hodgkin, P. D., Tarlinton, D. M., & Corcoran, L. M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3795 · Cited by 1,454
Mackay, F., & Schneider, P. (2009) · Nature Reviews Immunology · doi:10.1038/nri2572 · Cited by 930
B cell depletion therapies in autoimmune disease: advances and mechanistic insights
Lee, D. S. W., Rojas, O. L., & Gommerman, J. L. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-00092-2 · Cited by 658
B-cell biology and development
Pieper, K., Grimbacher, B., & Eibel, H. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.01.046 · Cited by 615
The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond
Dostert, C., Grusdat, M., Letellier, E., & Brenner, D. (2019) · Physiological Reviews · doi:10.1152/physrev.00045.2017 · Cited by 498
Metadata
- Authors
- Benson, M. J., Dillon, S. R., Castigli, E., Geha, R. S., Xu, S., Lam, K.-P., & Noelle, R. J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-03
- Volume
- 180
- Issue
- 6
- Pages
- 3655-3659
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1509863491
- Cited by
- 478
- References
- 0
- FWCI
- 12.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Benson, M. J., Dillon, S. R., Castigli, E., Geha, R. S., Xu, S., Lam, K.-P., & Noelle, R. J. (2008). Cutting Edge: The Dependence of Plasma Cells and Independence of Memory B Cells on BAFF and APRIL. The Journal of Immunology. https://doi.org/10.4049/jimmunol.180.6.3655
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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