The Role of WNT Signaling in Mature T Cells: T Cell Factor Is Coming Home
Open accessAbstract
T cell factor, the effector transcription factor of the WNT signaling pathway, was so named because of the primary observation that it is indispensable for T cell development in the thymus. Since this discovery, the role of this signaling pathway has been extensively studied in T cell development, hematopoiesis, and stem cells; however, its functional role in mature T cells has remained relatively underinvestigated. Over the last few years, various studies have demonstrated that T cell factor can directly influence T cell function and the differentiation of Th1, Th2, Th17, regulatory T cell, follicular helper CD4 + T cell subsets, and CD8 + memory T cells. In this paper, we discuss the molecular mechanisms underlying these observations and place them in the general context of immune responses. Furthermore, we explore the implications and limitations of these findings for WNT manipulation as a therapeutic approach for treating immune-related diseases.
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The Wnt signalling pathway is an important regulator in all developmental stages of T-cells.
“Furthermore, with regard to T-cell development, the Wnt signalling pathway has been described as an important regulator in all developmental stages of T-cells [42,43,44].”
From Nemo-Like Kinase in Development and Diseases: Insights from Mouse Studies (2020) · cites this paper as [44]
Haematopoietic, somatic and cancer stem cells in mice and humans have been identified via serial transplantation of limiting cell numbers into immunodeficient mice.
“Haematopoietic19, somatic14 and cancer stem cells20 in mice and humans have been identified via serial transplantation of limiting cell numbers into immunodeficient mice.”
From An autoimmune stem-like CD8 T cell population drives type 1 diabetes (2022) · cites this paper as [14]
The gold-standard assay to evaluate stem cell functions remains serial transplantation in animal models.
“The gold-standard assay to evaluate stem cell functions remains serial transplantation in animal models.”
From An autoimmune stem-like CD8 T cell population drives type 1 diabetes (2022) · cites this paper as [14]
TCF1 is one of the targets of canonical Wnt signalling, which maintains stemness in adult tissue stem cells, tumours, and peripheral T cells.
“TCF1 is one of the targets of canonical Wnt signalling, which maintains stemness in adult tissue stem cells, tumours, and peripheral T cells14,15.”
From An autoimmune stem-like CD8 T cell population drives type 1 diabetes (2022) · cites this paper as [14]
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References 75 · Cited by 50
- Authors
- van Loosdregt, J., & Coffer, P. J.
- Affiliations
- Division of Pediatrics, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht University , 3508 AB Utrecht ,
- Utrecht University (NL)
- Corresponding author
- Coffer, Paul J
- ORCID
- Coffer, Paul J
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-10
- Volume
- 201
- Issue
- 8
- Pages
- 2193-2200
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2896118093
- Cited by
- 50
- References
- 75
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 8 · 2023: 4 · 2022: 5 · 2021: 11 · 2020: 12 · 2019: 5
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- green
- dspace.library.uu.nl
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- Wnt signaling, T-cell factor, mature T cells, T cell differentiation, Th1 cells, Th2 cells, Th17 cells, regulatory T cells, T follicular helper cells, memory CD8+ T cells, T cell function, immune-related diseases
- MeSH terms
- Animals, Cell Differentiation, Humans, Immunologic Memory, Lymphocyte Activation, T-Lymphocytes, T-Lymphocyte Subsets, Cytokines, TCF Transcription Factors, Wnt Signaling Pathway
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