The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
RhoH Plays Critical Roles in FcεRI-Dependent Signal Transduction in Mast Cells
Abstract
RhoH is an atypical small G protein with defective GTPase activity that is specifically expressed in hematopoietic lineage cells. RhoH has been implicated in regulation of several physiological processes including hematopoiesis, integrin activation, and T cell differentiation and activation. In the present study, we investigated the role of RhoH in mast cells by generating RhoH knockout mice. Despite observing normal development of mast cells in vivo, passive systemic anaphylaxis and histamine release were impaired in these mice. We also observed defective degranulation and cytokine production upon FcεRI ligation in RhoH-deficient bone marrow-derived mast cells. Furthermore, FcεRI-dependent activation of Syk and phosphorylation of its downstream targets, including LAT, SLP76, PLCγ1, and PLCγ2 were impaired, however phosphorylation of the γ-subunit of FcεRI remained intact. We also found RhoH-Syk association that was greatly enhanced by active Fyn. Our results indicate that RhoH regulates FcεRI signaling in mast cells by facilitating Syk activation, possibly as an adaptor molecule for Syk.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Nonetheless, RhoH is required for FcεRI-dependent signal transduction in mast cells and thus passive systemic anaphylaxis and histamine release are impaired in the absence of RhoH72.”
From Hematopoietic-specific Rho GTPases Rac2 and RhoH and human blood disorders (2013) · cites this paper as [72]
In the citing paper
“T-cell development is impaired”
From RhoH is a negative regulator of eosinophilopoiesis (2016) · cites this paper as [26]
In the citing paper
“mast cell development unaffected. 21,26”
From RhoH is a negative regulator of eosinophilopoiesis (2016) · cites this paper as [26]
In the citing paper
“Rhoh -/-mice have a mild myeloid phenotype (39,40); no overt myeloid phenotype was observed in our patients.”
From Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections (2012) · cites this paper as [40]
Citations
Cites
Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores
Plaut, M., Pierce, J. H., Watson, C. J., Hanley-Hyde, J., Nordan, R. P., & Paul, W. E. (1989) · Nature · doi:10.1038/339064a0 · Cited by 1,170
THE HIGH-AFFINITY I g E RECEPTOR (FcεRI): From Physiology to Pathology
Kinet, J.-P. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.931 · Cited by 968
Integrated signalling pathways for mast-cell activation
Gilfillan, A. M., & Tkaczyk, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1782 · Cited by 955
Mast-cell responses to pathogens
Marshall, J. S. (2004) · Nature reviews. Immunology · doi:10.1038/nri1460 · Cited by 882
Bischoff, S. C. (2007) · Nature reviews. Immunology · doi:10.1038/nri2018 · Cited by 631
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
Turner, M., Joseph Mee, P., Costello, P. S., Williams, O., Price, A. A., Duddy, L. P., Furlong, M. T., Geahlen, R. L., & Tybulewicz, V. L. J. (1995) · Nature · doi:10.1038/378298a0 · Cited by 612
New developments in FcεRI regulation, function and inhibition
Kraft, S., & Kinet, J. (2007) · Nature reviews. Immunology · doi:10.1038/nri2072 · Cited by 604
Essential role for ZAP-70 in both positive and negative selection of thymocytes
Negishi, I., Motoyama, N., Nakayama, K., Nakayama, K., Senju, S., Hatakeyama, S., Zhang, Q., Chan, A. C., & Loh, D. Y. (1995) · Nature · doi:10.1038/376435a0 · Cited by 554
Syk tyrosine kinase required for mouse viability and B-cell development
Cheng, A. M., Rowley, B., Pao, W., Hayday, A., Bolen, J. B., & Pawson, T. (1995) · Nature · doi:10.1038/378303a0 · Cited by 528
Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases
Eiseman, & Bolen, J. B. (1992) · Nature · doi:10.1038/355078a0 · Cited by 487
Research works printed but not linked: 1
- 1999, The high-affinity IgE receptor (FcεRI): from physiology to pathology., 931
Cited by
Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses
Yi, Y., Son, Y., Ryou, C., Sung, G., Kim, J., & Cho, J. Y. (2014) · Mediators of Inflammation · doi:10.1155/2014/270302 · Cited by 182
Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections
Crequer, A., Troeger, A., Patin, E., Ma, C. S., Picard, C., Pedergnana, V., Fieschi, C., Lim, A., Abhyankar, A., Gineau, L., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62949 · Cited by 159
Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes
Patrick, M. S., Oda, H., Hayakawa, K., Sato, Y., Eshima, K., Kirikae, T., Iemura, S.-I., Shirai, M., Abe, T., Natsume, T., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908593106 · Cited by 85
Self-citationHitomi, K., Tahara‐Hanaoka, S., Someya, S., Fujiki, A., Tada, H., Sugiyama, T., Shibayama, S., Shibuya, K., & Shibuya, A. (2010) · Nature Immunology · doi:10.1038/ni.1886 · Cited by 75
Hematopoietic-specific Rho GTPases Rac2 and RhoH and human blood disorders
Troeger, A., & Williams, D. A. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.07.002 · Cited by 73
Metadata
- Authors
- Oda, H., Fujimoto, M., Patrick, M. S., Chida, D., Sato, Y., Azuma, Y., Aoki, H., Abe, T., Suzuki, H., & Shirai, M.
- Affiliations
- Department of Pathology, Research Institute, International Medical Center of Japan , Tokyo,
- Kanazawa University (JP)
- Yamaguchi University (JP)
- Kurume University (JP)
- RIKEN (JP)
- Corresponding author
- Oda, Hiroyo
- Chida, Dai
- Sato, Yoshinori
- Suzuki, Harumi
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-01
- Volume
- 182
- Issue
- 2
- Pages
- 957-962
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1495161304
- Cited by
- 29
- References
- 45
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Keywords
- RhoH, FcεRI signaling, mast cells, Syk activation, Fyn, passive systemic anaphylaxis, histamine release, mast cell degranulation, cytokine production, LAT, SLP-76, PLCγ1, PLCγ2, adaptor molecules
- MeSH terms
- Syk Kinase, Animals, Cell Differentiation, Cells, Cultured, Enzyme Activation, Mast Cells, Mice, Inbred C57BL, Passive Cutaneous Anaphylaxis, Protein-Tyrosine Kinases, Transcription Factors, Signal Transduction, Cell Degranulation, Receptors, IgE, Mice, Knockout, rho GTP-Binding Proteins, Intracellular Signaling Peptides and Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: RhoH Plays Critical Roles in FcεRI-Dependent Signal Transduction in Mast Cells. https://app.cochat.ai/papers/10.4049/jimmunol.182.2.957
- The paper
- Oda, H., Fujimoto, M., Patrick, M. S., Chida, D., Sato, Y., Azuma, Y., Aoki, H., Abe, T., Suzuki, H., & Shirai, M. (2009). RhoH Plays Critical Roles in FcεRI-Dependent Signal Transduction in Mast Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.182.2.957
