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Mast Cells and Local Resistance to Russell's Viper Venom
Abstract
Summary: It was observed that the subcutaneous injection of Russell's Viper venom initiated an explosive release of heparin-containing granules from local tissue mast cells and that the shed granules were subsequently ingested by fibroblasts and various other cell types involved in the connective tissue response to venom injury. Investigations of the significance of these cellular events indicated that heparin can form acid-base complexes with noxious factors of the venom in vitro and inhibit both local and systemic injury by this venom in mice. Inasmuch as this antivenom effect of heparin is only one aspect of a more general antitoxic activity of this mucopolysaccharide, it is suggested that the degranulation of mast cells may serve an important function in local resistance to injury by various cationic substances.
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In the citing paper
“Early work by Higginbotham and colleagues suggested that mast cells might be able to diminish the toxicity of certain venoms by degranulating and releasing heparin in response to venom exposure [76, 77].”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [76]
In the citing paper
“Notably, two different types of genetically mast cell-deficient mice also exhibited significantly diminished innate resistance to the toxicity and lethality of RVV (Fig. 6, A–C, E and F), supporting Higginbotham’s hypothesis that mast cells can contribute to enhanced innate resistance to this venom [76].”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [76]
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Mast cells and IgE in defense against venoms: Possible “good side” of allergy?
Galli, S. J., Starkl, P., Marichal, T., & Tsai, M. (2016) · Allergology International · doi:10.1016/j.alit.2015.09.002 · Cited by 73
Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy
Galli, S. J., Metz, M., Starkl, P., Marichal, T., & Tsai, M. (2020) · Allergo Journal International · doi:10.1007/s40629-020-00118-6 · Cited by 57
Metadata
- Authors
- Higginbotham, R. D.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1965-11-01
- Volume
- 95
- Issue
- 5
- Pages
- 867-875
- ISSN
- 1550-6606
- 0022-1767
- Cited by
- 41
- References
- 0
- Language
- en
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