Pathogenesis of Venezuelan Equine Encephalomyelitis Virus
Abstract
Summary: The pathogenesis of an attenuated and an unattenuated strain of Venezuelan equine encephalomyelitis virus infection in suckling mice as studied by infectivity titrations and direct fluorescent antibody-staining technique was described. Both strains of VEE virus caused a pantropic infection in suckling mice regardless of the concentration of inoculum used or the route of inoculation given. Viral antigen was detected in many tissues, notably in the central nervous system and in the pancreas. However the intensity of antigenic fluorescence was rather weak, making it difficult to discern sequential development of the viral antigen in infected tissues.
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VEEV infection induces neuropathology, including meningoencephalitis, gliosis, and multifocal neuropil vacuolation, localized to multiple regions including the hippocampus.
“It induces neuropathology, including meningoencephalitis, gliosis, and multifocal neuropil vacuolation, which is localized to multiple regions, including the hippocampus (Charles et al., 2001; Kundin et al., 1966; Schoneboom et al., 2000; A. Taylor et al., 2015).”
From Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model (2024) · cites this paper as Kundin et al., 1966
VEEV infection characteristically induces an intense inflammatory response, initiating perivascular and interstitial mononuclear infiltrate in the brain.
“VEEV infection characteristically induces an intense inflammatory response, initiating perivascular and interstitial mononuclear infiltrate in the brain.”
From Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model (2024) · cites this paper as Kundin et al., 1966
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Cited by 10
- Authors
- Kundin, W. D., Liu, C., & Rodina, P.
- Affiliations
- University of Kansas (US)
- ORCID
- Liu, Chien
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1966-01-01
- Volume
- 96
- Issue
- 1
- Pages
- 39-46
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W4313376849
- Cited by
- 10
- References
- 0
- Citations by year
- 2024: 1 · 2014: 1 · 2012: 1
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- Venezuelan equine encephalitis virus, pathogenesis, attenuated virus strains, suckling mice, viral antigen distribution, central nervous system infection, pancreatic infection, route of inoculation, infectivity titration
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