The DOI matches its Crossref record.
Characteristics of a Soluble Nuclear Antigen Precipitating with Sera of Patients with Systemic Lupus Erythematosus
Abstract
Summary: Sera of patients with systemic lupus erythematosus were demonstrated to contain precipitating antibodies to soluble tissue components other than DNA. One dominant reaction was observed which was provisionally termed the Sm system. The antigen involved was identified in nuclei of a wide variety of cells from different species. It was associated with protein fractions but was a non-histone substance quite sensitive to periodate treatment. Antibodies to the Sm antigen could also be detected by complement fixation. They showed a high incidence in systemic lupus erythematosus with considerable specificity for the disease.
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Citations
Cited by
Immunologic Factors and Clinical Activity in Systemic Lupus Erythematosus
Schur, P. H., & Sandson, J. (1968) · New England Journal of Medicine · doi:10.1056/nejm196803072781004 · Cited by 587
Identification of antibodies to nuclear acidic antigens by counterimmunoelectrophoresis
Kurata, N., & Tan, E. M. (1976) · Arthritis & Rheumatism · doi:10.1002/art.1780190309 · Cited by 373
Self-citationCell-Free DNA as a Biomarker in Autoimmune Rheumatic Diseases
Duvvuri, B., & Lood, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00502 · Cited by 282
Orton, S. M., Peace-Brewer, A., Schmitz, J. L., Freeman, K., Miller, W. C., & Folds, J. D. (2004) · Clinical and Vaccine Immunology · doi:10.1128/cdli.11.2.297-301.2004 · Cited by 35
Metadata
- Authors
- Tan, E. M., & Kunkel, H. G.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1966-03-01
- Volume
- 96
- Issue
- 3
- Pages
- 464-471
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W4313376993
- Cited by
- 481
- References
- 0
- FWCI
- 14.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Characteristics of a Soluble Nuclear Antigen Precipitating with Sera of Patients with Systemic Lupus Erythematosus. https://app.cochat.ai/papers/10.4049/jimmunol.96.3.464
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- Tan, E. M., & Kunkel, H. G. (1966). Characteristics of a Soluble Nuclear Antigen Precipitating with Sera of Patients with Systemic Lupus Erythematosus. The Journal of Immunology. https://doi.org/10.4049/jimmunol.96.3.464
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