GSK‐3 in Neurodegenerative Diseases
Lei, Peng, Ayton, Scott, Bush, Ashley I., Adlard, Paul A.·2011·International Journal of Alzheimer’s Disease
Cited by (181)
Items 101–181 of 181
- Involvement of ‘stress–response’ kinase pathways in Alzheimer's disease progressionGeorges Mairet‐Coello, Franck Polleux · 2014 · Current Opinion in Neurobiology
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- Radiofluorination of oxazole-carboxamides for preclinical PET neuroimaging of GSK-3Cassis Varlow, Andrew V. Mossine, Vadim Bernard‐Gauthier, Peter J. H. Scott, Neil Vasdev · 2021 · Journal of Fluorine Chemistry
- Computational Drug Repurposing for Neurodegenerative DiseasesKyriaki Savva, Margarita Zachariou, Anastasis Oulas, George Minadakis, Kleitos Sokratous, Nikolas Dietis, George M. Spyrou · 2019 · Elsevier eBooks
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and HealthspanSamuel Kakraba, Srinivas Ayyadevara, Nirjal Mainali, Meenakshisundaram Balasubramaniam, Suresh Bowroju, Narsimha Reddy Penthala, Ramani Atluri, Steven W. Barger, Sue T. Griffin, Peter Anthony Crooks et al. · 2023 · Pharmaceuticals
- Fluoxetine Inhibits Natural Decay of Long-Term Memory via Akt/GSK-3β SignalingJee Hyun Yi, JiaBao Zhang, Sang Yoon Ko, Huiyoung Kwon, Se Jin Jeon, Se Jin Park, Ji-Wook Jung, Byung C. Kim, Young Choon Lee, Dong Hyun Kim et al. · 2018 · Molecular Neurobiology
- Tau protein phosphorylation at Thr175 initiates fibril formation via accessibility of the N‐terminal phosphatase‐activating domainMatthew A Hintermayer, Kathryn Volkening, Alexander Joseph Moszczynski, Neil S. Donison, Michael Joseph Strong · 2019 · Journal of Neurochemistry
- A Closer Look into the Role of Protein Tau in the Identification of Promising Therapeutic Targets for Alzheimer’s DiseaseRubayat Islam Khan, Saif Shahriar Rahman Nirzhor, Barnaly Rashid · 2018 · Brain Sciences
- Upregulation of the PI3K/AKT and Nrf2 Pathways by the DPP-4 Inhibitor Sitagliptin Renders Neuroprotection in Chemically Induced Parkinson’s Disease Mouse ModelsRitu Soni, Vaishali Pankaj, Sudeep Roy, Amit Khairnar, Jigna Shah · 2025 · ACS Chemical Neuroscience
- Neuropathological Mechanisms of β-N-Methylamino-L-Alanine (BMAA) with a Focus on Iron Overload and FerroptosisHamed Kazemi Shariat Panahi, Mona Dehhaghi, Benjamin Heng, Darius J.R. Lane, Ashley Ian Bush, Gilles J. Guillemin, Vanessa X. Tan · 2022 · Neurotoxicity Research
- In Vivo Imaging and Kinetic Modeling of Novel Glycogen Synthase Kinase-3 Radiotracers [11C]OCM-44 and [18F]OCM-50 in Non-Human PrimatesKelly A. Smart, Ming‐Qiang Zheng, Daniel Holden, Zachary Felchner, Li Zhang, Yanjiang Han, Jim R. Ropchan, Richard E. Carson, Neil Vasdev, Yiyun Henry Huang · 2023 · Pharmaceuticals
- Tau Acts in Concert With Kinase/Phosphatase Underlying Synaptic DysfunctionXing Fan, Liye Xia, Zheng Zhou, Yanyan Qiu, Chenhao Zhao, Xiaomin Yin, Wei Qian · 2022 · Frontiers in Aging Neuroscience
- Diabetes in Pregnancy Adversely Affects the Expression of Glycogen Synthase Kinase-3β in the Hippocampus of Rat NeonatesJavad Hami, Razieh Karimi, Hossein Haghir, Mehran Gholamin, Ariane Sadr‐Nabavi · 2015 · Journal of Molecular Neuroscience
- Neuroinflammation to neurodegeneration: Boulevard of broken nervesAli Attiq, Sheryar Afzal, Hemavalli Raman, Waqas Ahmad · 2025 · International Immunopharmacology
- Hyperglycemia-Driven Insulin Signaling Defects Promote Parkinson’s Disease-like Pathology in MiceRitu Soni, Kirti Mathur, Hritik Rathod, Amit Khairnar, Jigna Shah · 2024 · ACS Pharmacology & Translational Science
- Decoding the Role of Neurotrophins in Glycogen Synthase Kinase 3-Beta Regulation in Alzheimer’s DiseaseShubham Nilkanth Rahmatkar, Damanpreet Singh · 2025 · Molecular Neurobiology
- Tideglusib Ameliorates Ischemia/Reperfusion Damage by Inhibiting GSK-3β and Apoptosis in Rat Model of Ischemic StrokeBalu Joshi, Devendra Singh, Himika Wasan, Uma Sharma, K.H. Reeta · 2022 · Journal of Stroke and Cerebrovascular Diseases
- The Possible Role of Naringenin in the Prevention of Alcohol-Induced Neurochemical and Neurobehavioral DeficitsNema Ali Soliman, Muhammad Tarek Abdel Ghafar, Norhan Ahmed AbuoHashish, Marwa A. Ibrahim, Asmaa Eid, Rehab M. El‐Gohary, Rehab E. Abo El Gheit, Amira Mostafa Elshamy · 2022 · Neurochemical Research
- Technical considerations in detection of HERV-K in amyotrophic lateral sclerosis: selection of controls and the perils of qPCRMarta Garcia Montojo, Wenxue Li, Avindra Nath · 2019 · Acta Neuropathologica Communications
- Synthesis and preliminary evaluation of novel PET probes for GSK-3 imagingSurendra Reddy Gundam, Aditya Bansal, Manasa Kethamreddy, Sujala Ghatamaneni, Val J. Lowe, Melissa Erin Murray, Mukesh K. Pandey · 2024 · Scientific Reports
- Neurodegenerative phosphoprotein signaling landscape in models of SCA3Anna Sergeevna Sowa, Taissia G. Popova, Tina Harmuth, Jonasz Jeremiasz Weber, Priscila Pereira Sena, Jana Schmidt, Jeannette Hübener‐Schmid, Thorsten Schmidt · 2021 · Molecular Brain
- Oligomeric and Fibrillar Species of Aβ42 Diversely Affect Human Neural Stem CellsAdela Bernabeu-Zornoza, Raquel Coronel, Charlotte Palmer, Victoria López-Alonso, Isabel Liste · 2021 · International Journal of Molecular Sciences
- Caloric restriction mimetic 2-deoxyglucose maintains cytoarchitecture and reduces tau phosphorylation in primary culture of mouse hippocampal pyramidal neuronsM. S. Bele, K. A. Gajare, A. A. Deshmukh · 2015 · In Vitro Cellular & Developmental Biology - Animal
- The Role of p53 in Alzheimer’s Disease: Impact on Tau PathologyMaja Jazvinšćak Jembrek, Katy Newberg, Goran Šimić · 2018 · Springer eBooks
- The A -Induced NFAT Apoptotic Pathway Is Also Activated by GSK-3 Inhibition: Implications for Alzheimer TherapeuticsScott Ayton, Peng Lei · 2012 · Journal of Neuroscience
- Glycogen synthase kinase-3: the master switch driving neurodegeneration in Alzheimer’s disease and Parkinson’s diseaseYifang Liu, Jingru Zhang, Luhong Tang, Jiaoyan Yang, Liying Hao, Fan Lou, Jingyang Su · 2025 · Archives of Toxicology
- Precision Enzyme: Targeted Drug Discovery in Neurodegenerative DisordersSampriti Paul, Prashant Kumar Tiwari, Sonal Dubey · 2025 · Protein and Peptide Letters
- Effect of JGK-263 as a new glycogen synthase kinase-3β inhibitor on extrinsic apoptosis pathway in motor neuronal cellsGye Sun Jeon, Jee‐Eun Kim, Suk-Won Ahn, Kyung Seok Park, Yoon‐Ho Hong, In-Hae Ye, Ji-Seon Park, Seung Hyun Kim, Kwang Woo Lee, Sung‐Min Kim et al. · 2013 · Biochemical and Biophysical Research Communications
- 18 F‐Radiopharmaceutical Diversification Enabled by Deaminative Cross‐Electrophile CouplingsIsabella F. Ogilvy, Joseph Ford, Sebastiano Ortalli, Evelien Renders, Thomas R. Hayes, Shuanglong Liu, Inne Mortiers, Anastasia Nikolopoulou, Alexandre M. Sorlin, Andrés A. Trabanco et al. · 2025 · Angewandte Chemie International Edition
- Reimagining GSK-3β Therapeutics in Alzheimer’s Disease: From Inhibition to Activity Normalization and Targeted DegradationEmad Manni, Hayder M. Al‐kuraishy, Rabab Eisawy, Ahmed M Abdelaziz, Gaber El‐Saber Batiha · 2026 · Journal of Molecular Neuroscience
- Analysing the role of Saraswatarishta in the treatment of neurological disorders based on network pharmacologyVrinda Jethalia, Sanjana Varada Hasyagar, Kasturi Bhamidipati, Jhinuk Chatterjee · 2021 · Neuroscience Research Notes
- The Effete of Lithium Chloride on the Granular Cell Density in Cerebellar Folia V and VI in a Trimethyltin Intoxication ModelSolmaz Shams-Alam, Mohammad Amin Edalatmanesh · 2015 · The Neuroscience Journal of Shefaye Khatam
- Long-term depression-related tau phosphorylation is enhanced by methylene blue in healthy rat hippocampusCem Süer, N. Yıldız Demircan, Özlem Barutçu, Burak Tan, Nurcan Dursun · 2021 · Pharmacological Reports
- Pathophysiological mechanism and natural preventive and therapeutic strategies of Alzheimer's diseaseAbdelkader Basli, Jihane Bounaas · 2022 · Nutrition and Health
- Rational Design of Dual Inhibitors for Alzheimer's Disease: Insights from Computational Screening of BACE1 and GSK-3βMagham Sai Varshini, Ramakkamma Aishwarya Reddy, Praveen Thaggikuppe Krishnamurthy, Divakar Selvaraj · 2023 · Current Computer - Aided Drug Design
- GSK-3: An “Ace” Among KinasesTheodore Lemuel Mathuram · 2024 · Cancer Biotherapy and Radiopharmaceuticals
- Evaluation of Nrf2/Keap1 Pathway in Patients with MigraineFatih Koçtürk, Firdevs Emekli, Kadir Eği, Seyithan Tayşi · 2025 · Medicina
- Insulin and TLR4 Inhibitor Improve Motor Impairments in a Rat Model of Parkinson’s DiseaseFatemeh Hemmati, Neda Valian, Abolhassan Ahmadiani, Zahurin Mohamed, Azman Ali Raymond, Norlinah Mohamed Ibrahim, Seyed Farshad Hosseini Shirazi · 2024 · Iranian journal of pharmaceutical research
- Modulating Role of TTR in Aβ Toxicity, from Health to DiseaseIsabel Cardoso, Luís Miguel Santos, Mobina Alemi · 2016 · InTech eBooks
- Decoding the Role of Nuclear Sirtuins in Parkinson’s PathogenesisDishank Patel, Ritu Soni, Jigna Shah · 2024 · ACS Chemical Neuroscience
- Investigation of the Mechanisms of Neuroprotection Mediated by Lobelia Species via Computational Network Pharmacology and Molecular ModelingQinfang Zheng, Liang-zi Fang, Xiaolong Huang, Ye Wang, Shuihan Zhang · 2020 · Research Square
- GLP1 secretagogue cinnamaldehyde upregulates GLP1/PI3K/AKT and Nrf2 pathways to exert neuroprotection in a rotenone induced mouse model of Parkinson's diseaseKirti Mathur, Ritu Soni, Ruchi Yadav, Bhumika Patel, Jigna Shah · 2025 · International Journal of Biological Macromolecules
- Anticancer Properties of Antipsychotic DrugsMilica Borovčanin, Bojan Stojanović, Milica Dimitrijevic Stojanovic, Bojana Stojanović, Aleksandar Lazovic, Marina M. Mitrović · 2024 · Interdisciplinary cancer research
- Comparison of [18F]F‐CNBI and [18F]F‐CNPIFE as Positron Emission Tomography Probes for Noninvasive Imaging of Glycogen Synthase Kinase‐3 in Normal MiceHeather M. Stein, Surendra R. Gundam, Aditya Bansal, Nicholas R. Nelson, Geoffry L. Curran, Timothy R. DeGrado, Mark A. Frye, John D. Port, Val J. Lowe, Melissa Erin Murray et al. · 2022 · European Journal of Organic Chemistry
- The Lithium Chloride Effect on Anxiety, Exploratory Activity, and Brain Derived Neurotrophic Factor Levels of the Hippocampus in a Rat Model of TMT IntoxicationMarzieh Moghadas, Mohammad Amin Edalatmanesh · 2015 · The Neuroscience Journal of Shefaye Khatam
- Trimethyltin can induce cell death in the entorhinal cortex of rat brain: a histological architecture and neuronal density evaluation of the neuroprotective role of lithium chlorideMahin Homayoon, Mohammad Amin Edalatmanesh, Marzieh Moghadas · 2014 · Comparative Clinical Pathology
- Proposed Prophylactic use of Lithium to improve Cognitive Decline and Mental Health in Disorders such as Alzheimerʼs Disease and DepressionJessica L Foster, Vincent S. Gallicchio · 2018 · Madridge Journal of Clinical Research
- Role of GSK-3 Inhibition in Alzheimer’s Disease TherapyHala Algazzawi, Jakleen Ziyad Abujamai, Asim Muhammed Alshanberi, Rukhsana Satar, Shakeel Ahmed Ansari · 2025 · Current Alzheimer Research
- Unraveling the Effects of GSK-3β Isoform Modulation against Limbic Seizures and in the 6 Hz Electrical Kindling Model for EpileptogenesisNajat Aourz, Fred VAN LEUVEN, Wissal Allaoui, Ann Van Eeckhaut, Dimitri De Bundel, Ilse Julia Smolders · 2022 · ACS Chemical Neuroscience
- Targeting Impaired Nutrient Sensing via the Glycogen Synthase Kinase-3 Pathway With Therapeutic Compounds to Prevent or Treat Dementia: A Systematic ReviewAdrian Matysek, Sumudu Perera Kimmantudawage, Lei Feng, Andrea Britta Maier · 2022 · Frontiers in Aging
- Sex differences in neuronal oscillatory activity and memory in the methylazoxymethanol acetate model of schizophreniaAbdalla M. Albeely, Olivia O. F. Williams, Colin R. Blight, Rachel-Karson Thériault, Melissa L. Perreault · 2024 · Schizophrenia Research
- Neurodegeneration: A Leg Up on TDP-43Matthew D. Figley, Aaron D. Gitler · 2015 · Current Biology
- TDZD-8 pre-treatment in transient middle cerebral artery occlusionBernardo Oliveira Ratilal, João Pedro Rocha, Adelaide Maria Afonso Fernandes, Mariana Moreira Coutinho Arroja, Andreia Pereira Barateiro, Dora Maria Tuna Oliveira Brites, Rui M. A. Pinto, Bruno Miguel Nogueira Sepodes, Hélder Mota‐Filipe · 2014 · Biomedicine & Aging Pathology
- Anti-parkinsonian efficacy of target-specific GSK3β inhibitors demonstrated in Caenorhabditis elegansHanumanthappa Pradeep, Shivaiah Shashikumar, P.S. Rajini, Golgodu Krishnamurthy Rajanikant · 2014 · Medicinal Chemistry Research
- Extrinsic Apoptosis Pathway Altered by Glycogen Synthase Kinase-3β Inhibitor Influences the Net Drug Effect on NSC-34 Motor Neuron-Like Cell SurvivalJee‐Eun Kim, Jung Hyun Lim, Gye Sun Jeon, Je-Young Shin, Suk-Won Ahn, Seung Hyun Kim, Kwang Woo Lee, Yoon‐Ho Hong, Jung‐Joon Sung · 2017 · BioMed Research International
- Contrasting Effects of Inhibitors Li + and Be 2+ on Catalytic Cycle of Glycogen Synthase Kinase-3βDavid J. Reilley, Zaher Arraf, Anastassia N. Alexandrova · 2021 · The Journal of Physical Chemistry B
- Reshaping cytoskeleton: different acts of modulatory compoundsPelin Zobaroğlu-Özer, Gamze Bora · 2020 · Istanbul Journal of Pharmacy
- Maternal Bisphenol A Exposure Induces Hippocampal‐Dependent Learning and Memory Deficits Through the PI3K/Akt/mTOR Pathway in Male Offspring RatsJiajia Ren, Wenjie Bai, Yi Guo, Qiling Liu, Yuxin Wang, Chong Wang · 2025 · Journal of Biochemical and Molecular Toxicology
- Glycogen synthase kinase-3 activation and dysregulation of amyloid transport receptors expression and shedding in HIV-induced Alzheimer’s disease-like pathology: modulatory effects of CCR5 antagonistsBiju Bhargavan, Narendran Annadurai, Georgette D. Kanmogne · 2025 · Acta Neuropathologica Communications
- Phosphatidylinositol-3-kinase/Protein Kinase B (PI3K/AKT) and Nucleotide-Binding Oligomerization Domain-like Receptor Family Pyrin Domain Containing 3 (NLRP3) Inflammasome Modulation Underlies the Neuroprotective Effects of Vildagliptin in a Rotenone-Induced Mouse Model of Parkinson’s DiseaseDishank Patel, Ritu Soni, Inderjeet Bhogal, Sudeep Roy, Jigna Shah · 2026 · ACS Pharmacology & Translational Science
- Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative MedicineDavide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi · 2026 · Medicinal Research Reviews
- Degenerative Brain Diseases and White Matter InjuryGeorge Bartzokis, Po H. Lu · 2013 · Springer eBooks
- HDAC Inhibitors as Novel Therapeutic Option Against Therapeutically Challenging Neurological DisordersShabir Ahmad Ganai · 2019 · Springer eBooks
- ELEMENTARY PATHOPHYSIOLOGY, TREATMENT, RISK FACTOR OF ALZHEIMER’S DISEASE2022 · International Research Journal of Modernization in Engineering Technology and Science
- Parkinson's DiseaseVaibhav Walia, Ashish Gakkhar, Munish Garg · 2018 · Advances in medical diagnosis, treatment, and care (AMDTC) book series
- PET and SPECT Studies of Ageing and Cardiovascular Risk Factors for Alzheimer’s DiseaseGeraldo F. Busatto, Jaqueline H. Tamashiro-Duran, Tania Correa de Toledo, Luiz Kobuti Ferreira, Fábio Duran, Carlos Alberto Buchpiguel · 2014 · Springer eBooks
- Use it and boost it: Cognitive and physical activities modulate cognition via BDNF-TrkB signalingClaire J. Scavuzzo · 2014 · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
- The Role of the Dopamine D5 Receptor and D1-D2 Receptor Heterooligomer Signalling in Rodent Prefrontal Cortex and CognitionDavid Pok Yik Yeung · 2015 · TSpace (University of Toronto)
- Redox Signalling in Dopaminergic Cell Death and SurvivalAjit Ray, Aditi Verma, Vijayalakshmi Ravindranath · 2017 · Royal Society of Chemistry eBooks
- HEALTHY AGINGConstantin Munteanu · 2013 · Romanian Association of Balneology eBooks
- Unprecedented prospects as forthcoming drug targets: New boulevard in the cure and treatment of neurodegenerative disordersDipanjan Karati, Swarupananda Mukherjee, Nandita Batabyal · 2024 · Elsevier eBooks
- 18 F‐Radiopharmaceutical Diversification Enabled by Deaminative Cross‐Electrophile CouplingsIsabella F. Ogilvy, Joseph Ford, Sebastiano Ortalli, Evelien Renders, Thomas R. Hayes, Shuanglong Liu, Inne Mortiers, Anastasia Nikolopoulou, Alexandre M. Sorlin, Andrés A. Trabanco et al. · 2025 · Angewandte Chemie
- Additional file 1 of Neurodegenerative phosphoprotein signaling landscape in models of SCA3Anna Sergeevna Sowa, Taissia G. Popova, Tina Harmuth, Jonasz Jeremiasz Weber, Pereira Sena, Priscila, Schmidt, Jana, Jeannette Hübener‐Schmid, Thorsten Schmidt · 2021 · Figshare
- Nutrigenomic influence of a curcumin-supplemented high glycemic diet on hippocampal microvasculature in male C57BL/6J miceEmilio Balbuena, Jennifer M. Rutkowsky, Saivageethi Nuthikattu, Amparo C. Villablanca, Dragan Milenković · 2026 · Frontiers in Nutrition
- Identification and Characterization of New Therapeutic Targets in Acute Myeloid LeukemiaLina Benajiba · 2018 · theses.fr (ABES)
- Neuroprotection of engineered Clostridium butyricum-pMTL007-GLP-1 in A53T α-synuclein (α-syn) mouse model via PI3K/AKT/GSK-3βXin Fang, Yue Wang, Zhenli Long, Bin Liao, Bo Wang, Daojun Hong, Jie Luo, Tingtao Chen · 2026 · Journal of Zhejiang University SCIENCE B
- Integrative bioinformatics and docking-based in silico toxicity assessment of plastic additives: Insights into neurotoxic, reproductive, and carcinogenic risks and associated molecular pathwaysVedika Jain, Sharda Bharti · 2026 · Food and Chemical Toxicology
- BindingDB Entry 50018638: Dual-target compounds for Alzheimer's disease: Natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR).BindingDB · 2024 · UC San Diego
- BindingDB Entry 50010629: Optimization of Indazole-Based GSK-3 Inhibitors with Mitigated hERG Issue andBindingDB · 2021 · UC San Diego
- BindingDB Entry 50017428: The Repertoire of Small-Molecule PET Probes for Neuroinflammation Imaging: Challenges and Opportunities beyond TSPO.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50046824: Evaluation of Improved Glycogen Synthase Kinase-3a Inhibitors in Models of Acute Myeloid Leukemia.BindingDB · 2016 · UC San Diego